Genotype–phenotype of carriage rates of the TC haplotype and homozygous TC haplotype in patients with Crohn’s disease at the time of diagnosis
| TC haplotype variants carriage rates at diagnosis | p Value | Homozygous mutant TC haplotype carriage rates at diagnosis | p Value | |
|---|---|---|---|---|
| The clinical features of the Crohn’s disease patients included in the study comparing carriage of the TC and homozygous TC haplotype showing the percentage carriage of each phenotypic variable compared with the percentage carriage of those without the phenotypic variable. The odds ratios with 95% confidence intervals for significant results are given in the text. | ||||
| *The presence or absence of evidence for Crohn’s disease activity in each location was based on evidence from endoscopy, biopsy, or barium follow through and was independent of disease activity elsewhere in the gastrointestinal tract (see text). | ||||
| †Perianal disease defined by the presence of fissures, perianal ulcers, abscesses, or fistulae but not by the presence of skin tags alone. | ||||
| ‡Perianal disease defined by the presence perianal ulcers, abscesses, or fistulae but not by the presence of skin tags or fissures. | ||||
| §These were patients who fulfilled the diagnostic criteria for Crohn’s disease but in whom the disease location did not fit with the Vienna classification. | ||||
| BMI, body mass index. | ||||
| Individual disease location* | ||||
| Oral | 79.2% v 75.3% | 0.68 | 20.8% v 18.1% | 0.75 |
| Oesophageal | 83.3% v 75.3% | 0.65 | 50% v 15.8% | 0.06 |
| Gastric antrum | 86.4% v 71.7% | 0.05 | 36.7% v 14.2% | 0.006 |
| Gastric body | 82.1% v 75.2% | 0.43 | 14.3 % v 18.2% | 0.78 |
| Duodenal | 86.9% v 74.6% | 0.19 | 26.1% v 17.5% | 0.33 |
| Jejunal | 78.6% v 76.8% | 0.84 | 17.8% v 18.2% | 0.96 |
| Ileal | 75.0% v 78.2% | 0.65 | 23.0% v 18.2% | 0.48 |
| Caecal | 75.2% v 79.3% | 0.65 | 18.8% v 17.2% | 0.84 |
| Sigmoid | 75.8% v 81.8% | 0.46 | 22.6% v 18.2% | 0.58 |
| Rectum | 77.6% v 73.7% | 0.61 | 22.4% v 23.7% | 0.86 |
| Perianal† | 78.9% v 74.0% | 0.46 | 22.5% v 22.0% | 0.93 |
| Perianal‡ | 83.3% v 75.3% | 0.59 | 27.8% v 22.2% | 0.45 |
| Weight <9th centile | 87.9% v 67.3% | 0.002 | 28.8% v 16.8% | 0.07 |
| Height <9th centile | 84.1% v 68.4% | <0.05 | 25.0% v 21.4% | 0.62 |
| BMI <9th centile | 79.6% v 61.1% | 0.02 | 27.8% v 16.8% | 0.11 |
| Location according to the Vienna classification28 | ||||
| Colonic | 77.8% v 75.9% | 0.80 | 28.9% v 21.1% | 0.28 |
| Ileal | 77.8% v 76.3% | 0.92 | 44.4% v 21.9% | 0.21 |
| Ileo-colonic | 67.6% v 78.4% | 0.18 | 17.6% v 24.3% | 0.40 |
| Upper GI | 78.3% v 74.7% | 0.57 | 20.5% v 25.3% | 0.45 |
| None§ | 85.7% v 76.0% | 0.55 | 14.3% v 23.4% | 1 |
| Behaviour according to the Vienna classification28 | ||||
| Inflammatory | 74.8% v 83.9% | 0.28 | 22.4% v 25.8% | 0.68 |
| Stricturing | 83.3% v 76.2% | 0.68 | 16.7% v 23.3% | 1 |
| Penetrating | 84.0% v 75.2% | 0.33 | 28.0% v 22.2% | 0.52 |
| Atopic disease | ||||
| Eczema | 69.8% v 77.3% | 0.27 | 15.9% v 26.1% | 0.12 |
| Asthma | 73.1% v 75.4% | 0.74 | 11.5% v 26.9% | 0.02 |
| Hayfever | 72.5% v 75.9% | 0.66 | 7.5% v 27% | 0.009 |
| All atopy | 60.0% v 76.3% | 0.16 | 0% v 25.3% | 0.02 |
| No atopy | 75.6% v 74.5% | 0.86 | 29.1% v 17.7% | 0.07 |