Table 1 Genetically modified vaccines used in clinical and immunological evaluation
VaccineParent strainCFAs expressedGenes deletedGenes added
ACAM2010WS-1858B serotype O71:H(NAMRU-3, Cairo)CFA/IaroC, ompC, ompFpStrep (plasmid-borne)
ACAM2007WS-3504D Serotype O39:H12 (NAMRU-3, Cairo)CS2, CS3aroC, ompC, ompFpStrep
ACAM2017ACAM2007CS1, CS2, CS3aroC, ompC, ompFCS1, pStrep
  • CFA, colonisation factor antigen; CS, coli surface.