Table 2 Correlations between systemic and mucosal IgA responses
ValueASCALSSerology
CFA/Ir0.100.300.68
pNSNS0.0005
CS1r0.330.470.60
pNS0.040.005
CS2r0.170.650.57
pNS0.0020.009
CS3r0.580.720.51
p0.007<0.0010.02
  • Spearman’s rank correlation coefficients (r) between whole gut lavage fluid-specific IgA and the three peripheral blood responses measured: antibody-secreting cell (ASC) responses, antibody concentration in lymphocyte supernatant (ALS) responses and specific IgA concentration in serum (Serology). For colonisation factor antigen (CFA/I), responses were compared following administration of ACAM2010 to 17 volunteers; for coli surface antigens CS1, CS2 and CS3, responses were compared following administration of vaccines 2007 or 2017 to 20 volunteers.

  • NS, not significant.