Value | ASC | ALS | Serology | |
CFA/I | r | 0.10 | 0.30 | 0.68 |
p | NS | NS | 0.0005 | |
CS1 | r | 0.33 | 0.47 | 0.60 |
p | NS | 0.04 | 0.005 | |
CS2 | r | 0.17 | 0.65 | 0.57 |
p | NS | 0.002 | 0.009 | |
CS3 | r | 0.58 | 0.72 | 0.51 |
p | 0.007 | <0.001 | 0.02 |
Spearman’s rank correlation coefficients (r) between whole gut lavage fluid-specific IgA and the three peripheral blood responses measured: antibody-secreting cell (ASC) responses, antibody concentration in lymphocyte supernatant (ALS) responses and specific IgA concentration in serum (Serology). For colonisation factor antigen (CFA/I), responses were compared following administration of ACAM2010 to 17 volunteers; for coli surface antigens CS1, CS2 and CS3, responses were compared following administration of vaccines 2007 or 2017 to 20 volunteers.
NS, not significant.