Table 2

 Results of sensitivity analyses

No. of trialsCombined relative risks (95% CI)
Initial hemostasisDefinitive hemostasisRebleedingNeed for surgeryMortality
Clips versus injections
    All trials81.01 (0.96 to 1.06)1.14 (1.00 to 1.30)0.49 (0.30 to 0.79)0.37 (0.15 to 0.90)1.45 (0.44 to 4.74)
    Study duration
        Shorter (< 4 weeks)40.99 (0.92 to 1.05)1.07 (0.87 to 1.32)0.59 (0.29 to 1.20)0.39 (0.12 to 1.27)1.64 (0.22 to 12.2)
        Longer (4 weeks)31.04 (0.97 to 1.11)1.23 (0.97 to 1.56)0.38 (0.18 to 0.80)0.34 (0.09 to 1.35)1.35 (0.31 to 5.89)
    Adjuvant proton pump inhibitors
        Yes21.00 (0.91 to 1.10)1.07 (0.94 to 1.21)0.59 (0.23 to 1.54)0.97 (0.06 to 14.8)2.97 (0.48 to 18.3)
        No61.01 (0.96 to 1.07)1.21 (0.98 to 1.49)0.46 (0.26 to 0.81)0.33 (0.12 to 0.86)0.68 (0.12 to 3.95)
    Quality
        High (> 3)30.99 (0.85 to 1.15)1.14 (0.75 to 1.74)0.62 (0.32 to 1.21)0.36 (0.09 to 1.46)0.51 (0.05 to 5.43)
        Low (3)51.03 (0.97 to 1.10)1.17 (1.06 to 1.29)0.39 (0.19 to 0.78)0.37 (0.11 to 1.20)2.18 (0.50 to 9.53)
Clips with injection versus injections
    All trials71.00 (0.95 to 1.05)1.13 (1.03 to 1.23)0.47 (0.28 to 0.76)0.23 (0.08 to 0.70)1.23 (0.45 to 3.37)
    Study duration
        Shorter (< 4 weeks)40.97 (0.83 to 1.13)1.11 (0.96 to 1.28)0.54 (0.22 to 1.36)0.31 (0.07 to 1.32)0.81 (0.10 to 6.33)
        Longer (4 weeks)31.06 (0.97 to 1.16)1.20 (1.07 to 1.35)0.30 (0.11 to 0.78)0.09 (0.01 to 1.63)1.68 (0.23 to 12.5)
    Adjuvant Proton pump inhibitors
        Yes40.98 (0.82 to 1.18)1.15 (1.03 to 1.29)0.31 (0.16 to 0.63)0.28 (0.07 to 1.02)0.70 (0.19 to 2.64)
        No31.00 (0.93 to 1.07)1.09 (0.94 to 1.25)0.80 (0.39 to 1.64)0.16 (0.02 to 1.29)3.07 (0.05 to 18.7)
    Quality
        High (> 3)30.97 (0.87 to 1.09)1.08 (0.85 to 1.37)0.45 (0.22 to 0.93)0.27 (0.05 to 1.35)2.87 (0.59 to 14.1)
        Low (3)41.04 (0.96 to 1.13)1.15 (1.03 to 1.29)0.48 (0.24 to 0.94)0.21 (0.05 to 0.94)0.53 (0.12 to 2.39)