Table 2

 Sensitivity, specificity, positive and negative predictive value of all studied markers in three “clinical situations”

Sensitivity (%)Specificity (%)Positive predictive value (%)Negative predictive value (%)
ACCA, Anti-chitobioside carbohydrate antibody; ALCA, anti-laminaribioside carbohydrate antibody; AMCA, anti-mannobioside carbohydrate antibody; EU, ELISA units; gASCA, anti-Saccharomyces cerevisiae antibody; GI, gastrointestinal inflammation; IBD, inflammatory bowel disease; Omp, outer membrane porin; pANCA, perinuclear anti-neutrophilic cytoplasmic antibody.
*pANCA accuracy to detect ulcerative colitis.
Crohn’s disease (n  =  913) vs. ulcerative colitis (n  =  272)
    gASCA (⩾50 EU)56.490.495.238.2
    ALCA (⩾70 EU)17.793.089.525.2
    ACCA (⩾90 EU)20.784.982.224.2
    AMCA (⩾90 EU)28.182.484.325.5
    Omp (⩾25 EU)29.180.583.425.3
    pANCA*37.390.052.682.8
IBD (n  =  1225) vs healthy controls (n  =  200)
    gASCA (⩾50 EU)44.899.099.622.7
    ALCA (⩾70 EU)14.998.598.415.9
    ACCA (⩾90 EU)19.385.589.114.7
    AMCA (⩾90 EU)25.992.095.216.8
    Omp (⩾25 EU)27.093.596.217.3
    pANCA17.297.597.716.2
IBD (n  =  1225) vs non-IBD GI (n  =  113)
    gASCA (⩾50 EU)44.898.299.614.1
    ALCA (⩾70 EU)14.999.199.59.7
    ACCA (⩾90 EU)19.384.192.98.8
    AMCA (⩾90 EU)25.992.997.510.4
    Omp (⩾25 EU)27.075.292.28.7
    pANCA17.293.896.89.4