Table 4

 Epithelial apoptotic ratio

TUNELDAPIn
Percentage of apoptotic epithelial cells in the sigmoid colon of controls, mild to moderately active CD and UC and CD in remission as measured by TUNEL and DAPI staining in thin sections. Both inflammatory bowel disease groups reflect mild to moderate inflammation (cf Methods). All values are means (SEM).
*p<0.001 compared with control.
†Not significant.
**p<0.01.
CD, Crohn’s disease; DAPI, 4′,6-diamidino-2-phenylindole; TUNEL, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelling; UC, ulcerative colitis.
Control1.9 (0.2%)1.9 (0.2%)10
Active CD5.2 (0.5%)*5.4 (0.3%)*10
CD in remission1.6 (0.5%)†2 (0.3%)†8
Active UC4 (0.5%)**4.2 (0.7%)**11