| 150 mg/day | 600 mg/day | 900 mg/day | |
| Overall incidence | 18.1% | 21.5% | 17.8% |
| (36/199) | (43/200) | (35/197) | |
| Total adverse reactions, n | 44 | 62 | 45 |
| Common adverse | |||
| reactions, n (%)* | |||
| Abdominal distension | 2 (1.0) | 2 (1.0) | 2 (1.0) |
| Upper abdominal pain | 2 (1.0) | 4 (2.0) | 2 (1.0) |
| Constipation | 3 (1.5) | 4 (2.0) | 2 (1.0) |
| Diarrhoea | 7 (3.5) | 8 (4.0) | 8 (4.1) |
| Dyspepsia | 3 (1.5) | 2 (1.0) | 2 (1.0) |
| Loose stool | 1 (0.5) | 6 (3.0) | 5 (2.5) |
| Stomach discomfort | 2 (1.0) | 2 (1.0) | 3 (1.5) |
| Pruritus | 3 (1.5) | 3 (1.5) | 2 (1.0) |
*The adverse reactions which were observed in 1% or more of the patients.