Table 1 Potential beneficial effect of diet-induced weight loss on non-alcoholic fatty liver disease

Main effect	Result
Reduced hepatic FFA supply	↓ TAG synthesis
	↓ Hepatic insulin resistance
	↓ Hepatic glucose output
	↓ ROS generation
	↓ Hepatocyte inflammation
Improved extrahepatic insulin sensitivity	↓ De novo lipogenesis (↓SREBP-1)
→ reduced circulating insulin levels	↑ VLDL export
	↓ Fibrosis
↓ Adipose tissue inflammation	↓ Pro-inflammatory cytokines
	↑ Leptin sensitivity (↓SOCS-1)
	↑ Adiponectin

FFA, free fatty acid; ROS, reactive oxygen species; SOCS, suppressor of cytokine signalling; SREBP, sterol regulatory element-binding protein; TAG, triacylglycerol;VLDL, very low-density lipoprotein.