The body weight, relative liver weight, and serum and hepatic lipids in constitutive androstane receptor (CAR)+/+ and CAR−/− mice fed the methionine and choline-deficient or control diet for 8 weeks
| CAR+/+ | CAR−/− | |||
|---|---|---|---|---|
| Control | MCD | Control | MCD | |
| CAR, constitutive androstane receptor; MCD, methionine and choline-deficient. | ||||
| Data are expressed as mean (SD). | ||||
| *p<0.05. | ||||
| **p<0.01 in comparison to control diet. | ||||
| †p<0.01 in comparison to CAR+/+ mice. | ||||
| Body weight (g) | 31 (1.4) | 24.4 (1.7)** | 29.6 (1.6) | 25.6 (1.5)** |
| Relative liver weight (%) | 4.5 (0.4) | 11.7 (2.5)** | 4.4 (0.3) | 8.2 (0.6)**† |
| Serum triglyceride (mg/dl) | 124 (35) | 63 (18)* | 124 (77) | 55 (22)** |
| Hepatic triglyceride (mg/g wet liver) | 76 (18) | 270 (27)* | 56 (25) | 286 (27)* |