Logistic regression analysis* on pre-treatment factors and sustained combined response† at year 1 post-treatment follow-up
| Factor | Odds ratio (95% CI) | p Value |
|---|---|---|
| Multivariate analysis of all treatment arms (n = 518). ALT, alanine aminotransferase; LAM, lamivudine; PEG-IFNα-2a, peginterferon α-2a. | ||
| *ITT analysis based on original patient population where patients with missing data were treated as non-responders; †combined response: normal ALT and DNA ⩽20 000 cp/ml; only patients with genotype A, B, C or D were included. | ||
| Age (10 year increase) | 0.80 (0.63 to 1.02) | 0.0687 |
| Gender (M v F) | 0.68 (0.34 to 1.37) | 0.2828 |
| Weight (10 kg increase) | 1.03 (0.81 to 1.30) | 0.8271 |
| ALT (baseline) | 1.00 (1.00 to 1.00) | 0.3970 |
| Log10 HBV DNA (baseline) | 1.06 (0.93 to 1.21) | 0.3612 |
| Genotype (A v D) | 2.58 (0.73 to 9.20) | 0.1432 |
| Genotype (B v D) | 3.69 (1.54 to 8.79) | 0.0033 |
| Genotype (C v D) | 5.46 (2.46 to 12.1) | <0.0001 |
| PEG-IFNα-2a v LAM | 2.11 (1.11 to 4.01) | 0.0223 |
| PEG-IFNα-2a+LAM v LAM | 2.16 (1.14 to 4.10) | 0.0185 |