HNPCC mut+ | ||
---|---|---|
intestinal*, MSI | intestinal, MSI | |
Decreased MMR protein expression | ||
MLH1 | 9/10 (90%) | 10/10 (100%) |
MSH2 | 1/10 (10%) | 0/10 (0%) |
MSH6 | 1/10 (10%) | 0/10 (0%) |
Nuclear β-catenin | 2/10 (20%) | 3/10 (30%) |
CTNNB1 exon 3 mutation | 0/10 (0%) | 0/10 (0%) |
APC LOH (strict) | 2/12 (17%) | 3/8 (38%) |
APC LOH (strict + putative) | 5/12 (42%) | 4/8 (50%) |
p53 positive IHC | 2/10 (20%) | 3/10 (30%) |
KRAS exon 2 mutation | 1/13 (8%) | 3/10 (30%) |
BRAF exon 15 mutation | 0/13 (0%) | 0/10 (0%) |