Molecular markers in HNPCC cancer and microsatellite instability

HNPCC mut+
intestinal*, MSIintestinal, MSI
Decreased MMR protein expression
MLH19/10 (90%)10/10 (100%)
MSH21/10 (10%)0/10 (0%)
MSH61/10 (10%)0/10 (0%)
Nuclear β-catenin2/10 (20%)3/10 (30%)
CTNNB1 exon 3 mutation0/10 (0%)0/10 (0%)
APC LOH (strict)2/12 (17%)3/8 (38%)
APC LOH (strict + putative)5/12 (42%)4/8 (50%)
p53 positive IHC2/10 (20%)3/10 (30%)
KRAS exon 2 mutation1/13 (8%)3/10 (30%)
BRAF exon 15 mutation0/13 (0%)0/10 (0%)