Echocardiographic, haemodynamic and humoral measures obtained before and 28 days after transjugular intrahepatic portosystemic shunt implantation in 32 patients with cirrhosis
| Variable | Before TIPS | After TIPS | p Value |
|---|---|---|---|
| E/A, early maximal filling velocity/late filling velocity; LVEDV, left ventricular end diastolic volume; LVESV, left ventricular end systolic volume; LVEF, left ventricular ejection fraction; RVSP, right ventricular systolic pressure; SVR, systemic vascular resistance; TIPS, transjugular intrahepatic portosystemic shunt. | |||
| *The reported data were obtained from 29 patients. | |||
| †The analysis was performed on 23 patients. In these patients, at baseline, plasma renin activity was 3.47 (0.78) ng/l⋅s, aldosterone 1548 (355) pmol/l and atrial natriuretic peptide 28 (4.2) pmol/l. | |||
| Mean arterial pressure (mm Hg) | 85 (2) | 86 (2) | 0.18 |
| Heart rate (bpm) | 73 (2) | 78 (2) | 0.043 |
| LVEDV (ml) | 94 (6) | 111 (5) | 0.001 |
| LVESV (ml) | 34 (3) | 42 (3) | 0.008 |
| LVEF (%) | 66 (2) | 63 (2) | 0.11 |
| Stroke volume (ml) | 61 (3) | 68 (3) | 0.010 |
| Cardiac output (l/min) | 4.4 (0.2) | 5.5 (0.2) | <0.001 |
| E/A ratio | 0.97 (0.05) | 1.19 (0.08) | 0.008 |
| Deceleration time (ms) | 234 (8) | 216 (8) | 0.16 |
| RVSP (mm Hg) | 23 (1) | 26 (2) | 0.43 |
| SVR (dyne s/cm5 m2) | 1639 (77) | 1310 (54) | <0.001 |
| Plasma renin activity (ng/l⋅s) | 3.2 (0.6)* | 2.0 (0.47)† | 0.026 |
| Aldosterone (pmol/l) | 1642 (319)* | 971 (164)† | 0.26 |
| Atrial natriuretic peptide (pmol/l) | 29 (3.9)* | 47 (7.46)† | 0.021 |