Table 1

 Risk of gastric adenocarcinoma for Helicobacter pylori serostatus, quintiles of serum pepsinogen I:II and quintiles of serum gastrin concentration according to different gastric subsites and adenocarcinoma subtypes

Risk factorCardia (44 cases, 132 controls)Non-cardia overall (129 cases, 376 controls)*Non-cardia, intestinal (59 cases, 173 controls)Non-cardia, diffuse (35 cases, 100 controls)Non-cardia, mixed (31 cases, 91 controls)
Values are represented as OR (95% CI).
*Including four histologically unclassifiable cases and 12 corresponding controls.
H pylori serostatus
    Negative1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    Positive0.27 (0.12 to 0.59)4.75 (2.56 to 8.81)3.96 (1.69 to 9.27)3.90 (1.11 to 13.7)5.51 (1.52 to 20.0)
    p Value0.001<0.0050.0020.0340.010
Serum pepsinogen I:II quintiles
    5th 6.060–30.9731.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    4th 4.803–6.0550.24 (0.07 to 0.75)1.21 (0.48 to 3.05)1.07 (0.30 to 3.74)0.31 (0.03 to 3.33)4.35 (0.44 to 43.4)
    3rd 3.777–4.7950.68 (0.27 to 1.74)2.49 (1.07 to 5.78)1.50 (0.47 to 4.82)2.02 (0.46 to 8.86)13.4 (1.20 to 150)
    2nd 2.691–3.7740.14 (0.03 to 0.71)5.35 (2.35 to 12.2)2.96 (0.94 to 9.29)7.82 (1.87 to 32.6)14.6 (1.35 to 157)
    1st 0.323–2.6880.78 (0.26 to 2.39)11.6 (4.91 to 27.5)12.5 (3.57 to 43.9)6.29 (1.45 to 27.3)24.9 (2.28 to 272)
    p Value for trend0.391<0.005<0.005<0.0050.002
Serum gastrin quintiles (ng/l)
    1st 2–201.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
    2nd 25–301.25 (0.44 to 3.55)1.99 (0.82 to 4.83)1.56 (0.44 to 5.52)8.19 (0.80 to 84.2)1.75 (0.30 to 10.2)
    3rd 35–551.58 (0.58 to 4.28)2.45 (1.13 to 5.35)1.82 (0.59 to 5.58)10.6 (1.13 to 99.0)1.66 (0.37 to 7.41)
    4th 60–900.71 (0.19 to 2.66)3.82 (1.77 to 8.23)3.66 (1.23 to 10.9)8.42 (0.97 to 73.2)3.44 (0.82 to 14.5)
    5th 95–4621.63 (0.48 to 5.48)8.99 (3.96 to 20.4)12.8 (3.83 to 42.6)21.8 (2.29 to 208)3.68 (0.77 to 17.7)
    p Value for trend0.702<0.005<0.0050.0070.042