Table 2

 Risk of adenocarcinoma for serum pepsinogen I:II <2.5 (relative to serum pepsinogen I:II >2.5) and serum gastrin concentration ⩾60 ng/l (relative to serum gastrin concentration <60 ng/l) according to gastric subsites and Helicobacter pylori serostatus

Gastric subsiteH pylori serostatus
Risk factorOverallSeropositiveSeronegative
Risk of adenocarcinoma estimated by OR with associated 95% CI in an unconditional logistic regression model with adjustment for the matching variables in the original study design.
*Unconditional logistic regression analysis without adjustment for the matching variables (only three cases with pepsinogen I:II <2.5 precluded adjustment).
†There were no H pylori seronegative cardia cases or controls with pepsinogen I:II <2.5.
Non-cardia129 cases, 376 controls116 cases, 247 controls13 cases, 129 controls
    Pepsinogen I:II >2.51.00 (reference)1.00 (reference)1.00 (reference)
    Pepsinogen I:II <2.54.47 (2.71 to 7.37)3.45 (2.01 to 5.91)12.6 (2.25 to 70.7)*
    p Value<0.001<0.0010.004
    Gastrin <60 ng/l1.00 (reference)1.00 (reference)1.00 (reference)
    Gastrin ⩾60 ng/l3.18 (2.03 to 4.99)2.77 (1.69 to 4.54)3.05 (0.71 to 13.1)
    p Value<0.001<0.0010.133
Cardia44 cases, 132 controls19 cases, 93 controls25 cases, 39 controls
    Pepsinogen I:II >2.51.00 (reference)1.00 (reference)1.00 (reference)
    Pepsinogen I:II <2.51.60 (0.62 to 4.14)3.33 (1.06 to 10.5)
    p Value0.3330.039
    Gastrin <60 ng/l1.00 (reference)1.00 (reference)1.00 (reference)
    Gastrin ⩾60 ng/l0.88 (0.37 to 2.06)2.23 (0.63 to 7.87)0.38 (0.05 to 3.03)
    p Value0.7610.2130.362