Risk of adenocarcinoma for serum pepsinogen I:II <2.5 (relative to serum pepsinogen I:II >2.5) and serum gastrin concentration ⩾60 ng/l (relative to serum gastrin concentration <60 ng/l) according to gastric subsites and adenocarcinoma subtypes
| Gastric subsite risk factor | Histology | |||
|---|---|---|---|---|
| Overall* | Intestinal | Diffuse | Mixed | |
| Risk of adenocarcinoma estimated by OR with associated 95% CI. | ||||
| *Including four histologically unclassifiable cases and 12 corresponding controls. | ||||
| – not applicable. | ||||
| Non-cardia | 129 cases, 376 controls | 59 cases, 173 controls | 35 cases, 100 controls | 31 cases, 91 controls |
| Pepsinogen I:II >2.5 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Pepsinogen I:II <2.5 | 4.32 (2.58 to 7.24) | 6.68 (2.79 to 16.0) | 3.21 (1.27 to 8.13) | 2.32 (0.86 to 6.25) |
| p Value | <0.001 | <0.001 | 0.014 | 0.097 |
| Gastrin <60 ng/l | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Gastrin ⩾60 ng/l | 2.97 (1.92 to 4.61) | 4.04 (2.05 to 7.96) | 2.11 (0.92 to 4.86) | 2.40 (1.06 to 5.44) |
| p Value | <0.001 | <0.001 | 0.079 | 0.036 |
| Cardia | 44 cases, 132 controls | 31 cases, 93 controls | 7 cases, 21 controls | 5 cases, 15 controls |
| Pepsinogen I:II >2.5 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Pepsinogen I:II <2.5 | 1.56 (0.60 to 4.09) | 0.72 (0.19 to 2.79) | 3.46 (0.32 to 37.5) | — |
| p Value | 0.365 | 0.632 | 0.307 | |
| Gastrin <60 ng/l | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Gastrin ⩾60 ng/l | 0.85 (0.38 to 1.88) | 0.59 (0.22 to 1.58) | 5.30 (0.52 to 54.6) | 0.69 (0.06 to 8.04) |
| p Value | 0.689 | 0.295 | 0.161 | 0.764 |