Results from the Sydney classification in HNPCC and sporadic gastric cancers
| Sydney classification | HNPCC | Sporadic | ||
|---|---|---|---|---|
| Intestinal MSI n = 10* | Intestinal MSI n = 10 | Intestinal MSS n = 20 | Diffuse MSS n = 16 | |
| HNPCC, hereditary non-polyposis colorectal cancer; MSI, microsatellite instability; MSS, microsatellite stable; N/A, not available/not applicable. | ||||
| *Of the 13 MMR gene mutation-positive gastric cancers, 10 were available for evaluation. | ||||
| Differentiation grade and tumour stage are also shown. | ||||
| Chronic inflammation | ||||
| Normal/none | 0 | 0 | 0 | 1 |
| Mild | 1 | 2 | 6 | 4 |
| Moderate | 2 | 4 | 10 | 7 |
| Marked | 7 | 4 | 4 | 4 |
| Neutrophils | ||||
| Normal/none | 3 | 6 | 6 | 11 |
| Mild | 7 | 3 | 11 | 2 |
| Moderate | 0 | 1 | 3 | 3 |
| Marked | 0 | 0 | 0 | 0 |
| Atrophy | ||||
| Normal/none | 3 | 5 | 4 | 10 |
| Mild | 2 | 2 | 10 | 2 |
| Moderate | 5 | 3 | 5 | 4 |
| Marked | 0 | 0 | 1 | 0 |
| Metaplasia | ||||
| Normal/none | 4 | 3 | 7 | 14 |
| Mild | 4 | 5 | 8 | 2 |
| Moderate | 2 | 2 | 2 | 0 |
| Marked | 0 | 0 | 3 | 0 |
| H pylori | ||||
| Normal/none | 8 | 5 | 9 | 12 |
| Mild | 2 | 3 | 5 | 4 |
| Moderate | 0 | 2 | 3 | 0 |
| Marked | 0 | 0 | 3 | 0 |
| Grade | n = 10* | n = 10 | n = 20 | n = 16 |
| Well differentiated (grade 1) | 1 | 1 | 5 | – |
| Moderately differentiated (grade 2) | 4 | 4 | 14 | – |
| Poorly differentiated (grade 3) | 4 | 5 | 1 | – |
| N/A | 1 | 0 | 0 | 16 |
| Stage | n = 13 | n = 10 | n = 20 | n = 16 |
| I | 2 | 1 | 8 | 3 |
| II | 5 | 4 | 6 | 1 |
| III | 5 | 3 | 5 | 6 |
| IV | 1 | 2 | 1 | 6 |