Table 4

 Summary of molecular data on hereditary non-polyposis colorectal cancer (mismatch repair gene germline mutation positive) and sporadic gastric cancers

HNPCC mut+Sporadic
Intestinal*, MSIIntestinal, MSIIntestinal, MSSDiffuse, MSS
HNPCC, hereditary non-polyposis colorectal cancer; MMR, DNA mismatch repair; MSI, microsatellite instability; MSS, microsatellite stable; ND, not done.
*Twelve intestinal and one diffuse
† Of the 24 studied genes
Values are given as proportion of tumours with alterations (percentage) unless specified otherwise.
Decreased MMR protein expression:n (%)n (%)n (%)n (%)
    MLH19/10 (90)10/10 (100)NDND
    MSH21/10 (10)0/10 (0)NDND
    MSH61/10 (10)0/10 (0)NDND
Nuclear β-catenin2/10 (20)3/10 (30)8/20 (35)3/16 (19)
CTNNB1 exon 3 mutation0/10 (0)0/10 (0)0/12 (0)0/16 (0)
APC LOH (strict)2/12 (17)3/8 (38)8/20 (40)0/16 (0)
APC LOH (strict + putative)5/12 (42)4/8 (50)12/20 (60)1/16 (6)
p53 positive IHC2/10 (20)3/10 (30)6/20 (30)4/16 (25)
KRAS exon 2 mutation1/13 (8)3/10 (30)0/20 (0)0/16 (0)
BRAF exon 15 mutation0/13 (0)0/10 (0)0/20 (0)0/16 (0)
Proportion of tumours with unstable loci:
    PTEN (A6)0/13 (0)1/10 (10)0/20 (0)0/16 (0)
    ACVR2 (A8)13/13 (100)10/10 (100)NDND
    BLM (A9)0/12 (0)1/10 (10)NDND
    MBD4 (A10)2/11 (18)4/10 (40)NDND
    TGFβRII (A10)8/13 (62)9/10 (90)0/20 (0)0/16 (0)
    MRE11 (T11)12/13 (92)8/10 (80)0/11 (0)0/14 (0)
Average number of methylated genes†4,15,92,31,6
MLH1 promoter methylation0/13 (0)7/10 (70)0/20 (0)0/16 (0)
TIMP3 promoter methylation5/13 (38)6/10 (60)3/20 (15)2/16 (13)
ESR1 promoter methylation5/13 (38)7/10 (70)6/20 (30)5/16 (31)
CHFR promoter methylation7/13 (54)9/10 (90)5/20 (25)2/16 (13)