Table 3 Comparison of clinical data between fatty liver alone and different stages of non-alcoholic steatohepatitis (NASH) fibrosis
CharacteristicFatty liver aloneNASH stage 0NASH stage 1–2NASH stage 3–4p Value
Age (years)47 (11)46 (11)47 (11)55 (11)<0.001
Body mass index (kg/m2)32 (5)33 (6)33 (6)35 (7)<0.001
    ⩾3077 (66%)40 (80%)211 (73%)114 (79%)
Female62 (39%)26 (36%)210 (53%)123 (63%)<0.001
Ethnicity
    Caucasian79 (52%)34 (69%)190 (70%)92 (83%)<0.001
    African–American17 (11%)4 (8%)8 (3%)5 (4%)
    Hispanic54 (35%)11 (2%)65 (24%)12 (11%)
    Asian Pacific Islander3 (2%)0 (0)8 (3%)2 (2%)
Hypertension73 (47%)41 (70%)177 (61%)100 (69%)<0.001
Diabetes23 (15%)15 (23%)115 (34%)106 (60%)<0.001
Alanine aminotransferase (ALT) (U/l)68 (37)80 (37)92 (72)67 (44)<0.001
Aspartate aminotransferase (AST) (U/l)42 (19)47 (20)62 (44)70 (45)<0.001
AST/ALT ratio0.7 (0.3)0.6 (0.3)0.8 (0.3)1.2 (0.5)<0.001
QUICKI0.318 (0.029)0.295 (0.026)0.303 (0.030)0.293 (0.020)<0.001
Hyperlipidaemia
    Neg103 (65%)33 (51%)179 (52%)109 (66%)0.002
    Pos55 (35)32 (49%)166 (48%)55 (34%)
  • QUICKI, quantitative assessment check index.