| Symptom item and studies reporting | Sensitivity (95% CI) | Specificity (95% CI) | Positive likelihood ratio (95% CI) | Negative likelihood ratio (95% CI) |
| Rectal bleeding | ||||
| Tate 198832 | 64% (35% to 87%) | 65.5% (56% to 74%) | 1.86 (1.07 to 2.77) | 0.55 (0.25 to 0.96) |
| Brenna 199033 | 96% (79% to 100%) | 40% (35% to 46%) | 1.61 (1.32 to 1.80) | 0.10 (0.02 to 0.50) |
| Berkowitz 199328 | 79% (49% to 95%) | 61% (55% to 67%) | 2.03 (1.33 to 2.57) | 0.35 (0.12 to 0.78) |
| Neugut 199336 | 77% (66% to 86%) | 34% (31% to 37%) | 1.17 (1.0 to 1.31) | 0.67 (0.43 to 1.0) |
| Brewster 199430 | 33% (15% to 57%) | 65.5% (61% to 70%) | 0.97 (0.49 to 1.62) | 1.02 (0.69 to 1.28) |
| Steine 199429 | 31.5% (19.5% to 45.5%) | 85% (83% to 86%) | 2.06 (1.33 to 2.98) | 0.81 (0.65 to 0.94) |
| Cheong 200035 | 55% (31.5% to 77%) | 72% (66% to 77%) | 1.95 (1.18 to 2.82) | 0.63 (0.36 to 0.93) |
| Morini 200127 | 70% (53.5% to 83%) | 37% (31% to 42%) | 1.10 (0.85 to 1.33) | 0.82 (0.49 to 1.28) |
| de Bosset 200231 | 49% (35% to 63%) | 71% (68% to 74%) | 1.71 (1.23 to 2.24) | 0.71 (0.53 to 0.90) |
| Selvachandran 200218 | 86% (78% to 92.5%) | 31% (29% to 33%) | 1.25 (1.12 to 1.34) | 0.45 (0.26 to 0.72) |
| Panzuto 200334 | 44% (28.5% to 60%) | 60% (53% to 66%) | 1.09 (0.72 to 1.54) | 0.94 (0.68 to 1.21) |
| Ahmed 200516 | 63% (45% to 78.5%) | 25% (21% to 29.5%) | 0.84 (0.62 to 1.04) | 1.49 (0.90 to 2.24) |
| Bjerregaard 200717 | 68% (59% to 76%) | 47% (45% to 49%) | 1.28 (1.11 to 1.44) | 0.68 (0.52 to 0.87) |
| Thompson 200719 | 71% (67% to 75%) | 37% (36% to 38%) | 1.13 (1.06 to 1.20) | 0.78 (0.67 to 0.89) |
| Summary measures | 64% (55% to 73%) | 52% (42% to 63%) | 1.32 (1.19 to 1.47) | 0.76 (0.66 to 0.87) |
| Change in bowel habit | ||||
| Tate 198832 | 64% (35% to 87%) | 78% (70% to 85.5%) | 2.98 (1.64 to 4.79) | 0.46 (0.21 to 0.79) |
| Berkowitz 199328 | 7% (0.2% to 34%) | 73% (67.5% to 78%) | 0.26 (0.05 to 1.19) | 1.27 (0.93 to 1.42) |
| Neugut 199336 | 12% (6% to 22%) | 83% (80.5% to 86%) | 0.72 (0.38 to 1.31) | 1.06 (0.94 to 1.13) |
| Brewster 199430 | 38% (18% to 62%) | 82% (77% to 85%) | 0.98 (0.53 to 1.55) | 1.01 (0.67 to 1.32) |
| Steine 199429 | 45% (32% to 69%) | 61% (56% to 66%) | 1.00 (0.72 to 1.29) | 1.00 (0.76 to 1.24) |
| Cheong 200035 | 25% (9% to 49%) | 81% (76% to 86%) | 1.34 (0.58 to 2.66) | 0.92 (0.65 to 1.11) |
| Morini 200127 | 12.5% (4% to 27%) | 94% (90% to 96%) | 1.95 (0.78 to 4.57) | 0.93 (0.79 to 1.02) |
| Selvachandran 200218 | 86% (78% to 92.5%) | 28% (26% to 29.5%) | 1.19 (1.07 to 1.28) | 0.50 (0.29 to 0.80) |
| Panzuto 200334 | 19.5% (9% to 35%) | 79.5% (74% to 84%) | 0.95 (0.48 to 1.76) | 1.01 (0.82 to 1.16) |
| Bjerregaard 200717 | 63% (54% to 72%) | 55% (53% to 57%) | 1.40 (1.20 to 1.60) | 0.67 (0.52 to 0.83) |
| Thompson 200719 | 77% (73% to 81%) | 56% (55% to 57%) | 1.76 (1.66 to 1.85) | 0.41 (0.35 to 0.48) |
| Summary measures | 41% (23% to 60%) | 69% (58% to 78%) | 1.29 (1.05 to 1.59) | 0.82 (0.66 to 1.01) |
| Anaemia | ||||
| Tate 198832 | 7% (0.2% to 34%) | 91% (85% to 96%) | 0.83 (0.14 to 4.18) | 1.02 (0.75 to 1.12) |
| Berkowitz 199328 | 7% (0.2% to 34%) | 84% (80% to 88%) | 0.46 (0.08 to 2.09) | 1.10 (0.81 to 1.20) |
| Cheong 200035 | 2% (0% to 20%) | 95% (92% to 98%) | 0.52 (0.05 to 4.53) | 1.02 (0.85 to 1.07) |
| Morini 200127 | 15% (6% to 30%) | 93% (90% to 96%) | 2.24 (0.96 to 4.89) | 0.91 (0.76 to 1.00) |
| de Bosset 200231 | 12% (4% to 24%) | 90% (87% to 92%) | 1.14 (0.52 to 2.35) | 0.98 (0.85 to 1.06) |
| Panzuto 200334 | 68% (52% to 82%) | 83% (77% to 87%) | 3.98 (2.77 to 5.59) | 0.38 (0.24 to 0.57) |
| Bjerregaard 200717 | 11% (6% to 18.5%) | 90% (89% to 92%) | 1.19 (0.71 to 1.95) | 0.98 (0.90 to 1.03) |
| Summary measures | 17% (5.5% to 33%) | 90% (87% to 92%) | 1.43 (0.75 to 2.74) | 0.96 (0.87 to 1.06) |
| Weight loss | ||||
| Steine 199429 | 31% (19% to 45%) | 81% (79% to 83%) | 1.65 (1.07 to 2.38) | 0.85 (0.69 to 0.98) |
| de Bosset 200231 | 8% (2% to 19%) | 97% (96% to 98%) | 3.01 (1.10 to 7.85) | 0.95 (0.84 to 1.00) |
| Selvachandran 200218 | 18% (11% to 27%) | 92% (91% to 94%) | 2.39 (1.50 to 3.67) | 0.89 (0.79 to 0.96) |
| Panzuto 200334 | 37% (22% to 53%) | 89% (84% to 92%) | 3.24 (1.86 to 5.41) | 0.71 (0.54 to 0.87) |
| Bjerregaard 200717 | 21% (14% to 30%) | 79% (77% to 81%) | 1.03 (0.71 to 1.43) | 0.99 (0.89 to 1.08) |
| Summary measures | 22% (14% to 31%) | 89% (81% to 95%) | 1.96 (1.25 to 3.08) | 0.91 (0.84 to 0.98) |
| Diarrhoea | ||||
| Tate 198832 | 14% (2% to 42%) | 78% (70% to 86%) | 0.66 (0.18 to 2.0) | 1.09 (0.76 to 1.29) |
| Morini 200127 | 1% (0% to 11%) | 95% (92% to 97%) | 0.26 (0.03 to 2.37) | 1.04 (0.94 to 1.07) |
| de Bosset 200231 | 2% (0% to 10%) | 89% (87% to 91%) | 0.18 (0.03 to 0.94) | 1.10 (1.01 to 1.14) |
| Selvachandran 200218 | 69.5% (59% to 78.5%) | 61% (59% to 63%) | 1.78 (1.52 to 2.02) | 0.50 (0.36 to 0.66) |
| Panzuto 200334 | 24% (12% to 40%) | 69% (62% to 74%) | 0.78 (0.43 to 1.31) | 1.10 (0.87 to 1.30) |
| Summary measures | 19% (1% to 54%) | 80% (63% to 93%) | 0.74 (0.34 to 1.62) | 0.98 (0.85 to 1.13) |
| Iron deficiency anaemia | ||||
| Tate 198832 | 7% (0% to 34%) | 91% (85% to 96%) | 0.83 (0.14 to 4.18) | 1.02 (0.75 to 1.12) |
| Berkowitz 199328 | 7% (0% to 34%) | 84% (80% to 88%) | 0.46 (0.08 to 2.09) | 1.10 (0.81 to 1.20) |
| de Bosset 200231 | 12% (4% to 24%) | 90% (87% to 92%) | 1.14 (0.52 to 2.35) | 0.98 (0.85 to 1.06) |
| Panzuto 200334 | 68% (52% to 82%) | 83% (77% to 87%) | 3.98 (2.77 to 5.59) | 0.38 (0.24 to 0.57) |
| Summary measures | 23% (2%% to 57%) | 87% (83% to 91%) | 1.38 (0.48 to 3.94) | 0.88 (0.68 to 1.13) |
| Abdominal mass | ||||
| Cheong 200035 | 5% (0% to 29%) | 96% (93% to 98%) | 1.37 (0.23 to 7.27) | 0.99 (0.79 to 1.04) |
| Bjerregaard 200717 | 4% (1% to 9%) | 97% (96% to 98%) | 1.50 (0.62 to 3.51) | 0.99 (0.93 to 1.01) |
| Summary measures | 5% (2% to 9%) | 97% (96% to 98%) | 1.47 (0.68 to 3.19) | 0.99 (0.95 to 1.02) |
| Dark red rectal bleeding | ||||
| Selvachandran 200218 | 7% (3% to 15%) | 97% (97% to 98%) | 2.71 (1.28 to 5.57) | 0.95 (0.88 to 0.99) |
| Bjerregaard 200717 | 24% (17% to 32%) | 94% (93% to 95%) | 4.27 (2.94 to 6.07) | 0.81 (0.72 to 0.88) |
| Summary measures | 15% (3% to 34%) | 96% (93% to 98%) | 3.83 (2.62 to 5.61) | 0.88 (0.75 to 1.04) |
| Statistical models | ||||
| Bellentani 199026 | 95% (65% to 100%) | 54% (48% to 61%) | 2.10 (1.47 to 2.46) | 0.08 (0.01 to 0.59) |
| Selvachandran 200218 | 91% (83% to 96%) | 62% (60% to 64%) | 2.38 (2.16 to 2.57) | 0.15 (0.08 to 0.28) |
| Summary measures | 90% (84% to 95%) | 59% (52% to 66%) | 2.35 (2.16 to 2.55) | 0.15 (0.08 to 0.26) |