Status of oesophageal epithelium | Number of subjects | Median (IQR) fundic leptin (pg/mg) | OR (95% CI)* | p-value |
Normal | 44 | 126 (78–221) | 1.00 | – |
Inflamed | 24 | 114 (76–195) | 0.99 (0.61 to 1.6) | 0.99 |
Barrett’s | 20 | 202 (123–333) | 3.39 (1.5 to 7.6) | 0.003 |
*Odds of having either inflamed or Barrett’s esophagus compared with normal oesophagus (no pathology) for every twofold increase in fundic leptin. Analysis controls for patient age, ethnicity, body mass index, use of proton pump inhibitors and gastric pH.
IQR, interquartile range.