TableA.12 Summary of articles identified through systematic search by section

ID and authorsResearch setting and year of studyStudy designSample sizeTopic of documentLevel of evidenceQuality score (AGREE) (%)
Section 3.1 Spectrum of disease
Jenkins541UK (2001)Commentary, review of evidenceNAPaediatric IBD352
Cumberland et al358UK (not specified—circa 2003)Survey and follow-up85 Practices; over 1000 casesInfectious intestinal disease in England2−73
Dominitz et al783USA (not specified—circa 2002; data between 1987 and 1996)Analysis of routine dataSample taken from 746 130 birthsInfants born to mothers with IBD2+66
Sheridan et al745UK (1990)Analysis of routine data; survey100 Patients; 52 cliniciansAbdominal pain and resource implications2−73
De Lillo and Rose784International (2000)Commentary; appraisal of evidenceAround 50 articlesBowel disorders in geriatric patients357
Hislop and Heading785UK (2000–01)Survey and analysis of routine data53 cliniciansImpact of alcohol related disease2−61
Lunniss et al359UK (data taken between 1995 and 2002)Analysis of patient data629 PatientsFaecal incontinence2−66
McKiernan et al373UK (1993–95)Analysis of patient data; survey93 CasesBiliary atresia2−64
Plevris et al786International, with emphasis on UK (1998)Commentary; review of evidenceAround 120 articlesManagement of acute liver failure361
Morris787International (1991)Commentary; review of researchAround 80 articlesNon-ulcer dyspepsia359
AGA788USA (2001)Review of evidence; expert commentaryOver 125 articlesPrevalence and costs of GI diseases2+68
De Dombal544International; emphasis on UK (1994)Commentary; review of evidenceAround 7 articlesAcute abdominal pain357
Section 3.2 Incidence (includes prevalence)
Jenkins541UK (2001)Commentary; review of evidenceNAPaediatric IBD352
Cumberland et al358UK (Not specified—circa 2003)Survey and follow-up85 Practices; over 1000 casesInfectious intestinal disease (IID) in England2+73
Bodger737International, with emphasis on UK (2002)Commentary; appraisal of evidenceAround 60 articlesCost of illness of Crohn’s disease366
Hislop and Heading785UK (2000–01)Survey and analysis of routine data53 CliniciansImpact of alcohol related disease2−61
Gut Week103UK (2004)Public information leaflets; commentaryNADigestive health in the UK336
Lunniss et al359UK (data between 1995 and 2002 taken)Analysis of patient data629 PatientsFaecal incontinence2−66
Ghanchi and Rembacken789UK (2003)Review of evidence; commentaryAround 130 articlesIBD370
Morris787International (1991)Commentary; review of researchAround 80 articlesNon-ulcer dyspepsia359
Mamula et al790International; emphasis on USA (data between 1977 and 2000 taken)Analysis of routine data82 PatientsIBD in children under 5 years of age2−70
AGA788USA (2001)Review of evidence; expert commentaryOver 125 articlesPrevalence and costs of GI diseases2+68
McNamara et al581International; emphasis on USA (2000)Review of evidence; expert commentaryAround 70 articlesNon-ulcer dyspepsia (NUD)2−64
Wong et al791China and Hong Kong (2002)Survey of Chinese population2209 Survey responsesGastro-oesophageal reflux disease (GERD)2−80
Pimentel et al792USA (not specified—circa 2000)Survey; analysis of patient data448 PatientsSmall intestinal bacterial overgrowth (SIBO) and IBS2+66
De Dombal544International; emphasis on UK (1994)Commentary; review of evidenceAround 7 articlesAcute abdominal pain357
Loftus102International (2004)Review of evidenceAround 170 articlesIBD2−59
Russel793International (2000)Review of evidence; commentaryAround 50 articlesIncidence of IBD355
Moum and Ekbom794International (2002)Review of evidenceAround 90 articlesIncidence of IBD355
Wilson et al153International (2003)Systematic review15 ArticlesPrevalence of IBD166
Farrokhyar et al795International (literature between 1950 and 1999 taken)Review of evidenceAround 200 articlesEpidemiology of IBD166
Lapane et al796USA (data between 1992 and 1996 taken)Analysis of patient data133 839 Patient recordsEffect of NSAID use2+68
Chiang et al797Australia (2001)Analysis of patient data167 PatientsAcute pancreatitis management2+68
Fass et al798USA (1992–95)Analysis of patient data; survey505 PatientsFunctional bowel disorders (FBD) and sleep disorders2−73
Parry et al799UK (2000–01)Case-control study482 PatientsIBS and bacterial gastroenteritis2+75
Bernstein et al800Canada and USA (data between 1984 and 1996 taken)Analysis of dataNot specified, but a large numberExtra-intestinal diseases in IBD2−59
Payne and Saul801UK (data between 1994 and 1998 taken)Survey and analysis of data12 239 ResponsesCommon disorders in long term illnesses2−61
Ruigomez et al802UK (1994)Analysis of data2956 PatientsFollow-up of patients with IBS2−50
Sanders et al174UK (1999–2001)Cross sectional intervention1200 ParticipantsDiagnosis of coeliac disease2+70
Waddell and Hislop357UK (not specified—circa 1999 onwards)Analysis of patient data390 PatientsImpact of alcohol related disease2−59
BSG574UK (2002)GuidelinesNAGuidelines for dyspepsia management2−45
ONS803UK (2001)National dataCancer trends between 1950 and 1999Cancer trends in England and Wales2+66
Kennedy and Jones22UK (Not specified—circa 1997–2000)Cross sectional survey3179 Survey responsesPrevalence of gastro-oesophageal reflux symptoms2−64
Watson et al144UK (data between 1980 and 1999 taken)Retrospective study of patient data107 PatientsIBD in children2−57
Rockall et al91UK (1993)Analysis of patient data4185 CasesIncidence and mortality from GI haemorrhage2−57
Metcalf et al243UK (data between 1987 and 1994 taken)Analysis of patient data160 CasesIncidence and prevalence of primary biliary cirrhosis in Newcastle Upon Tyne2−61
Blower et al804UK (1990–91)Analysis of routine data620 CasesUpper GI disease and NSAID use2+57
Sawczenko et al805UK (1999)Survey739 ResponsesChildhood IBD2−50
James et al238UK (data between 1987 and 1994 taken)Collection and analysis of patient data770 CasesPrimary biliary cirrhosis2−52
McKay et al306UK (data between 1984 and 1995 taken)Analysis of patient dataOver 10 000 casesAcute pancreatitis2−57
Griffin et al806UK (2002)Analysis and summary of patient data3361 CasesSummary of incidence and mortality rates for upper GI cancers343
Cooper et al807UK (2001)Analysis of NHS Direct dataOver 150 000 callsCalls to NHS Direct and GI diseases2−55
CSCG808UK (2003)CommentaryNAResponse to NICE service guidance on upper GI cancersGuideline41
Jones809International (1999)Review of evidenceAround 20 articlesMethodological considerations368
Feuer595International (1999)Commentary; review of evidenceAround 20 articlesManagement of intestinal obstruction350
NHS, NICE810UK (2004)National commentary; guidelines; recommendationsNAImproving the outcomes in colorectal cancerGuideline70
South Wales Cancer Network754UK (2003)Service guidelines; recommendationsNAConfiguration of services345
Aerts and Penninckx266Europe (2003)Review of evidence; commentaryAround 30 articlesBurden of gallstone disease2−52
Ashorn811Europe (2003)Review of evidence; commentaryAround 20 articlesPaediatric GI disease343
Delvaux210Europe (2003)Review of evidence; commentaryAround 30 articlesDiverticular disease of the colon348
Delvaux812Europe (2003)Review of evidence; commentaryAround 40 articlesFaecal incontinence355
Delvaux813Europe (2003)Review of evidence; commentaryAround 30 articlesFunctional bowel disorders and IBS350
McNamara319Europe (2003)Review of evidence; commentaryAround 40 articlesPancreatic disease350
Burroughs and McNamara227Europe (2003)Review of evidence; commentary;Around 30 articlesLiver disease350
Talley et al53USA (1987–90)Survey of random sample of population328 Survey responsesPrevalence of gastrointestinal symptoms in the elderly2−70
Section 3.3 Mortality
Gut Week103UK (2004)Public information leaflets; commentaryNADigestive health in the UK336
Munkholm814International (2003)Review of evidence; commentaryAround 25 articlesIncidence and prevalence of colorectal cancer357
AGA788USA (2001)Review of evidence; expert commentaryOver 125 articlesPrevalence and costs of GI diseases2+68
de Dombal544International; emphasis on UK (1994)Commentary; review of evidenceAround 7 articlesAcute abdominal pain357
Davis et al815International (1990)Analysis of dataData from 1968 to 1987International cancer mortality trends2−64
Stanley et al816International (1988)Review of trendsAround 20 articlesMortality trends2−59
Khan et al817International (data between 1979 and 1998 taken)Analysis of mortality dataNot specified, but a large amount of dataMortality trends2−57
Cucino and Sonnenberg818USA (data between 1991 and 1996 taken)Analysis of mortality dataData of around 5000 patient deathsOccupational mortality2−57
Farrokhyar et al795International (literature between 1950 and 1999 taken)Review of evidenceAround 200 articlesEpidemiology of IBD166
Maroun et al819Canada (not clear—circa late 1990s)Analysis of data; review of evidenceNA; cases taken from databasesCosts of cancer management2−73
Fernandez et al820Europe (data between 1955and 1989 taken)Analysis of dataNot specified (but a large amount)Trends in pancreatic cancer mortality2+61
La Vecchia et al821Europe (data between 1970 and 1996 taken)Analysis of dataNot specified (but a large amount)Trends in primary liver cancer mortality2+55
Maheswaran et al822UK (1993–95)Analysis of mortality dataOver 10 000 casesTrends in stomach cancer2+61
Taylor-Robinson et al446UK (data between 1968 and 1996 taken)Analysis of mortality dataA large amountMortality rates from intrahepatic cholangiocarcinoma2−57
ONS803UK (2001)National dataCancer trends between 1950 and 1999Cancer trends in England and Wales2+66
Payne et al823UK (1991)Cross sectional survey3877 Survey responsesComparison of prevalence rates2−73
Rockall et al91UK (1993)Analysis of patient data4185 CasesIncidence and mortality from GI haemorrhage2−57
Sharp et al824UK (data between 1968 and 1992)Analysis of cancer dataNot specified, but a large amountCancer incidence and mortality2−50
Blower et al804UK (1990–1991)Analysis of routine data620 CasesUpper GI disease and NSAID use2+57
Pye et al825UK (1995–1996)Analysis of patient data910 PatientsCarcinoma of the oesophagus and stomach2−57
James et al238UK (data between 1987 and 1994 taken)Collection and analysis of patient data770 CasesPrimary biliary cirrhosis2−52
McKay et al306UK (data between 1984 and 1995 taken)Analysis of patient dataOver 10 000 casesAcute pancreatitis2−57
Bray et al328Europe (1995)Analysis of mortality dataNot specified, but a large amountCancer incidence and mortality2+66
AUGIS826UK (2002)Analysis and summary of patient data3361 CasesSummary of incidence and mortality rates for upper GI cancers343
Rockall et al398UK (1993–94)Collection and analysis of patient dataOver 5000 casesOutcomes after acute upper GI haemorrhage2−57
Tekkis et al827UK (1999–2001)Analysis of patient data8077 PatientsOperative mortality in colorectal cancer2−70
NHS, NICE671UK (2004)National commentary; guidelines; recommendationsNAImproving the outcomes in colorectal cancerGuideline70
South Wales Cancer Network754UK (2003)Service guidelines; recommendationsNAConfiguration of services345
Burroughs and McNamara227Europe (2003)Review of evidence; commentaryAround 30 articlesLiver disease350
Section 3.4 Morbidity
Morris787International (1991)Commentary; review of researchAround 80 articlesNon-ulcer dyspepsia359
Waddell and Hislop357UK (not specified—circa 1999 onwards)Analysis of patient data390 PatientsImpact of alcohol related disease2−59
Payne et al828UK (1991)Cross sectional survey3877 Survey responsesComparison of prevalence rates2−73
McCulloch et al829UK (1999–2002)Cohort study; analysis of patient data955 PatientsMortality and morbidity in gastro-oesophageal cancer surgery2−64
Smith et al775UK (not specified—circa 2003)Survey of people with IBS symptoms486 CasesManagement of IBS in primary and secondary care2−66
Spechler20International (1992)Review of researchAround 30 articlesEpidemiology of GERD366
Section 3.5 Geographical variation
Talley et al830International (not specified—circa 1995 to 2000)Survey of communitiesOver 5000 survey responsesClassification of GI symptoms2−70
Wong et al791China and Hong Kong (2002)Survey of Chinese population2209 Survey responsesGastro-oesophageal reflux disease (GERD)2−80
Loftus102International (2004)Review of evidenceAround 170 articlesIBD2−59
Russel793International (2000)Review of evidence; commentaryAround 50 articlesIncidence of IBD355
Moum and Ekbom794International (2002)Review of evidenceAround 90 articlesIncidence of IBD355
Farrokhyar et al795International (literature between 1950 and 1999 taken)Review of evidenceAround 200 articlesEpidemiology of IBD166
Maheswaran et al822UK (1993–95)Analysis of mortality dataOver 10 000 casesTrends in stomach cancer2+61
Bray et al328Europe (1995)Analysis of mortality dataNot specified, but a large amountCancer incidence and mortality2+66
Levenstein et al831International (data between 1991 and 1996 taken)Survey of patients2002 PatientsCross-cultural variation in patients with IBD2−75
Section 3.6 Socioeconomic factors
Dominitz et al783USA (not specified—circa 2002; data between 1987 and 1996)Analysis of routine dataSample taken from 746 130 birthsInfants born to mothers with IBD2−66
Hislop and Heading785UK (2000–01)Survey and analysis of routine data53 CliniciansImpact of alcohol related disease2−61
Neumann and Cooper32UK (data between 1989 and 1996 taken)Analysis of patient data1101 PatientsEthnic differences in gastro-oesophageal disease2−68
Wong et al791China and Hong Kong (2002)Survey of Chinese population2209 Survey responsesGastro-oesophageal reflux disease (GERD)2−80
Loftus102International (2004)Review of evidenceAround 170 articlesIBD2−59
Longobardi et al832USA (1999)Analysis of data23 649 RecordsWork losses due to IBD2−66
Longobardi et al833Canada (1999)Analysis of data23,649 RecordsWork losses due to IBD2−66
Fass et al798USA (1992–95)Analysis of patient data; survey505 PatientsFunctional bowel disorders (FBD) and sleep disorders2−73
Danese et al834International (2004)Expert commentary; summary of evidenceAround 40 articlesIBD and environmental factors348
Payne and Saul801UK (data between 1994 and 1998 taken)Survey and analysis of data12 239 ResponsesCommon disorders in long term illnesses2−61
Kennedy and Jones22UK (not specified—circa 1997–2000)Cross sectional survey3179 Survey responsesPrevalence of gastro-oesophageal reflux symptoms2−64
McKinney et al835UK (data between 1960 and 1990)Analysis of cancer dataNot specified, but a large numberOesophageal and gastric cancer incidence2−52
Bray et al328Europe (1995)Analysis of mortality dataNot specified, but a large numberCancer incidence and mortality2+66
Dean et al836USA (1999)Survey of patients11 604 ResponsesWork productivity and gastro-oesophageal reflux disease (GERD)2−75
Bernstein et al837Canada (1995–96)Survey and analysis of patient dataNot clear, but a large numberSocioeconomic factors associated with IBD2−55
Sands et al552USA (patients between 1991 and 1997)Analysis of patient data345 PatientsRisk of early surgery for Crohn’s disease2+64
Vaughn et al838UK (not specified—circa 1998)Survey of patients and their relativesNot clear—around 29 patientsExpressed emotion during the course of IBD2−59
Crane and Martin839UK (not specified—circa 2002)Survey of patients58 PatientsSocial learning, affective state, and passive coping in IBD and IBS2−68
Sewitch et al534Canada (Not specified—circa 2001)Survey of patients and physicians10 Gastroenterologists and 200 patientsPatient-physician correlates in IBD2−75
Casati and Toner840International (2000)Review of evidence; commentaryAround 70 articlesPsychosocial aspects of IBD355
Sewitch et al841Canada (1999)survey of patients200 PatientsPsychosocial aspects in IBD370
Soo et al842International (studies from 1966 to present)Systematic review4 StudiesPsychological interventions for non-ulcer dyspepsia2−80
Guthrie843International (2002)Review of evidence3 StudiesPsychodynamic-interpersonal therapy for functional bowel disorders352
Kisely844UK (1996–97)Analysis of patient data65 204 Patient recordsMultiple readmissions2−59
Moum585International (2000)Review of evidenceAround 80 articlesMedical treatment for IBD364
Tojek et al845USA (not specified—circa 2000)Survey of patients62 PatientsHealth status in IBD2−75
Jahnsen et al846Norway (not specified—circa 2003)Population based study60 PatientsBody composition in patients with IBD2+66
de Rooy et al687Canada (not specified—circa 2001)Survey of patients259 PatientsConcerns of patients with IBD2−68
Ward et al738International (circa 1998)Review of evidenceAround 40 articlesManagement of IBD2−70
Hatch847Not specified—appears to be USA (circa 1996)Case study2 PatientsTreatment of bowel obsessions370
Guthrie et al848UK (not specified—circa 2003)Survey of patients; analysis of patient data107 PatientsCluster analysis to define patient subgroups for IBS2−75
Drossman849International (1999)Review of evidenceAround 40 articlesPsychosocial factors in IBS366
Payne et al823UK (1991)Survey of population in Rotherham3877 Survey responsesDeprivation and morbidity2−70
Section 3.7 Quality of life
Pachler and Wille-Jorgensen850International (2002–03 (no restriction on date of studies)Systematic review8 StudiesQuality of life (QoL) after rectal resection for cancer175
Yacavone et al851International (review of evidence: 1966 to 1999)Review of evidenceAround 80 articlesQoL in gastroenterology2+68
Simren et al852Sweden (not specified—circa 2002)Survey of patients83 PatientsQoL in IBD2−66
Rubin et al676UK (not specified—circa 2003)Survey of patients409 ResponsesQoL in IBD2−68
Halder et al450USA (not specified—circa 2003)Case-control study112 Patients; 110 controlsGI disorders and QoL2+66
Hahn et al853UK and USA (not specified—circa 1999)Survey of patientsAround 600 patientsImpact of IBS on QoL2−66
Blondel-Kucharski et al854France (not specified—circa 2001)Survey of patients231 PatientsQoL in Crohn’s disease2−66
Akehurst et al740UK (1998)Survey of patients161 PatientsQoL and cost impact of IBS2+77
Gonsalkorale et al855UK (not specified—circa 2002)Survey of patients78 PatientsCognitive change in patients during IBS2−70
Moayyedi and Mason747UK (1992–94)Analysis of patient data; survey of patientsNot clear; over 8000 patientsEconomic consequences of dyspepsia382
Borgaonkar and Irvine447International (2000)Review of evidence between 1966 and 1999Around 140 articlesQoL measurement in gastrointestinal and liver disorders2+80
El-Serag et al856International (2001)Systematic review of evidence between 1980 and 200117 articlesArticlesQoL of people with IBS1+77
Koloski et al449Australia (not clear—circa 1996–2000)Survey of random sample of population2910 Survey respondentsImpact of functional GI disorders on QoL2−70
O’Keefe et al857USA (1987–90)Survey of random sample of population530 Survey responsesBowel disorders and its impact on QoL in the elderly2−75
Gralnek et al858USA (1994–1998)Survey of patients877 PatientsImpact of IBS on health related QoL2−73
Section 4.1 Care pathways
McNamara et al581International; emphasis on USA (2000)Review of evidence; expert commentaryAround 70 articlesNon-ulcer dyspepsia (NUD)2−64
Association of Coloproctology of GB and Ireland505UK (2001)Specification of guidelinesNAGuidelines for the management of colorectal cancerGuideline61
CSCG808UK (2003)CommentaryNAResponse to NICE service guidance on upper GI cancersGuideline41
Pfau et al859USA (1997–1999)Implementation of care pathway421 patientsClinical care pathway for the management of acute nonvariceal upper GI bleeding2−77
Kisely844UK (1996–1997)Analysis of patient data65204 patient recordsMultiple readmissions2−59
Feuer595International (1999)Commentary; review of evidenceAround 20 articlesManagement of intestinal obstruction350
Section 4.2 Workforce
Garvican607UK (1998)Commentary; cost analysisNAColorectal cancer screening370
Duff et al506UK (2002)Audit65 PatientsWaiting times for treatment of rectal cancer in northwest England352
Slade et al860UK (not specified—circa 1998)Survey of patients; treatment intervention232 PatientsSerological testing for H pylori to reduce workload2−61
Lamy and McNamara861Europe (data between 1996 and 2001)Survey of expertsNot clear—around 25 European countriesGastroenterology and hepatology services in Europe359
Association of Coloproctology of GB and Ireland753UK (2001)Analysis of audit data; expert commentary and recommendations8 Main sources of audit dataResources for coloproctology352
Section 4.3.1 Primary care
Cumberland et al358UK (not specified—circa 2003)Survey and follow-up85 Practices; over 1000 casesInfectious intestinal disease (IID) in England2+73
Section 4.3.2 Inpatients
Hislop and Heading785UK (2000–01)Survey and analysis of routine data53 CliniciansImpact of alcohol related disease2−
Waddell and Hislop357UK (Not specified—circa 1999 onwards)Analysis of patient data390 patientsImpact of alcohol related disease2−
Section 4.3.3 Outpatients
Rayner et al862UK (1997–98)Analysis of patient data1203 PatientsOutpatient review practices2−57
Section 4.3.4 Procedures
Westbrook et al863Australia (data between 1986 and 1990 taken)Analysis of patient dataUnclear—over 17 000 casesUpper GI tract investigations in the elderly2−61
Grassi864Italy (data between 1991 and 1999)Commentary on dataNot clear, but a large numberEndoscopy activity436
BSG865UK (1987)Commentary; review of evidenceAround 20 articlesRequirements for colonoscopy357
Section 4.6.1 Access
Froehlich et al500Switzerland; comparisons with UK (1994–95)Review of evidence; analysis of patient data8135 PatientsOveruse of upper GI endoscopy in primary care2−61
Gralnek501International (2002)CommentaryNAOutpatient management of low risk non-variceal upper GI haemorrhage450
Silcock and Bramble502UK (1994)Survey333 ResponsesSurvey of current practice in open access gastroscopy (OAG)2−68
Section 4.6.2 Inequalities
Watt503UK (2002)CommentaryNAThe inverse care law439
Section 4.6.3 Waiting lists
Association of Coloproctology of GB and Ireland505UK (2001)Specification of guidelinesNAGuidelines for the management of colorectal cancerGuideline61
Flashman et al507UK (2000–01)Audit249 PatientsTwo week standard for bowel cancer2−61
Duff et al506UK (2002)Audit65 PatientsWaiting times for treatment of rectal cancer in northwest England352
Parente et al866Italy (1999–2000)Audit142 PatientsAudit of gastroscopy2−61
Dunnill and Pounder504UK (articles between 1966 and 2002)Literature reviewAround 40 articlesOutpatient services2−70
Hellier508UK (1999–2001)Survey of GI units210 GI unitsTwo week target for investigation cancer patients355
Section 4.6.4 Patient safety
Van Kouwen et al522Netherlands (1994–98)Analysis of endoscopy services and patient data218 PatientsUpper GI endoscopy for older patients2−57
Navarro and Hanauer509International (2003)Review of evidence; commentaryAround 70 articlesSafe treatment for IBD359
Akehurst and Kaltenthaler510International (trials between 1987 and 1998)Review of RCTs45 RCTsTreatment of IBS166
Dick et al511UK (2002)Analysis of prescriptions308 Patientsand 777 prescriptionsUse of unlicensed and off-label drugs in paediatric GI diseases2−61
Chan and Graham512International (2004)Review of evidenceAround 60 articlesPrevention of NSAID GI complications373
Sheen and Colin-Jones513International; emphasis on UK (2001)Review of evidenceAround 100 articlesOver-the-counter drugs for GI diseases368
Abbas et al520Not specified—circa 2003)Survey of patients; analysis of patient data1287 PatientsOutpatient upper GI endoscopy2−64
Bloor and Maynard514UK (1996)Review of evidenceAround 40 articlesPrescription of NSAIDs373
Feagan515International (2003)Review of evidenceAround 90 articlesMaintenance treatment for IBD2+61
Ripamonti et al526International (1993)Literature reviewAround 40 articlesManagement of bowel obstruction in patients with cancer2−75
Cook et al517International (articles from 1966 onwards)Meta-analysis30 RCTsEndoscopic therapy for acute non-variceal upper GI haemorrhage173
Page et al524USA (Patientsbetween 1989 and 1999)Analysis of patient dataOver 100 patientsSurgical risk in elderly patients with IBD2−59
Moorthy et al525UK (data between 1991 and 2001)Analysis of patient data48 PatientsPatients undergoing laparoscopic surgery for Crohn’s disease2−64
Yim et al527Not specified—probably USA (1996–99)Analysis of patient data29 PatientsEnteral stents for patients with upper GI obstruction2+64
Heuschkel et al518USA and UK (2000)Survey of patients208 Survey responsesComplementary medicine used by children for IBD2−80
Quine et al521UK (1991)Survey of clinicians39 Hospitals; 383 cliniciansAudit of upper GI endoscopy2−64
Section 4.6.5 Information to patients and practitioners
Dick et al511UK (2002)Analysis of prescriptions308 Patients and 777 prescrip-tionsUse of unlicensed and off-label drugs in paediatric GI diseases2−61
Sheen and Colin-Jones513International; emphasis on UK (2001)Review of evidenceAround 100 articlesOver-the-counter drugs for GI diseases368
Sewitch et al534Canada (not specified—circa 2001)Survey of patients and physicians10 Gastroenterologists and 200 patientsPatient-physician correlates in IBD2−75
Stone et al141UK (2002)Analysis of patient dataOver 86 000 patientsManagement of IBD2−73
Sewitch et al535Canada (1999)Survey of patients and clinicians10 Clinicians; 153 patientsPatient non-adherence to medication in IBD2−75
Mansfield et al537UK (not specified—circa 1997)Survey of clinicians and patients732 Patients; 6 gastroenterology clinicsInformation for patients about IBD2−64
Thompson et al532UK (not specified—circa 2003)Survey of patients and nurses402 Patients; 62 nursesInformation for patients undergoing gastroscopy2−73
Hawkey and Hawkey530UK (not specified—circa 1989)Survey of patients751 Survey responsesInformation for patients with GI diseases2−70
NICE671UK (2004)Summary of guidelinesNAInformation leaflet for patients330
Greiner et al536USA (2002)Survey of patientsNot clear—around 800 patientsBarriers to colorectal cancer screening2−70
Institute of Food Research529UK (2004)Information and advice to the publicNADiet and health341
Mukherjee et al528UK (not specified—circa 2001)Qualitative study24 PatientsParents’ experiences of IBD2−75
Section 4.6.6 Diagnosis and complications in care
Jenkins541UK (2001)Commentary, review of evidenceNAPaediatric IBD352
Mamula et al790International; emphasis on USA (data between 1977 and 2000 taken)Analysis of routine data82 PatientsIBD in children under 5 years of age2−70
de Dombal544International; emphasis on UK (1994)Commentary; review of evidenceAround 7 articlesAcute abdominal pain357
Gatta et al561Europe (not specified—data collected between 1988 and 1999)Analysis of cancer data2720 PatientsColorectal cancer in Europe2−59
Camilleri543USA (2001)Review of evidence; commentaryAround 170 articlesManagement of IBS364
Limpert et al554USA (patients between 1992 and 2002 were usedAnalysis of patient data181 PatientsColon and rectal cancer in the elderly2−61
Sanders et al174UK (1999–2001)Cross sectional intervention1200 ParticipantsDiagnosis of coeliac disease2+70
Spray et al540UK (patients between 1994 and 1998 were used)Analysis of medical recordsAround 100 patientsIBD in children2+52
Hamilton and Sharp556UK (evidence between 1966 and 2002 taken)Assessment of clinical guidelinesAround 100 articlesGuidelines for the diagnosis of colorectal cancer2+66
Ofman et al545USA (not specified—circa 2002)Application of decision analysisNAManagement strategies for gastro-oesophageal reflux disease2−75
Brignoli et al548Switzerland (not specified—circa 1997)Case-control study1078 PatientsDiagnostic strategies for dyspepsia2+70
Summerton and Paes549UK (1997–98)Survey; audit275 ResponsesClinical assessment of patients with large bowel symptoms2−70
Farmer et al539USA (not specified—circa 2000)Evaluation of practice; analysis of patient data119 PatientsDiagnostic accuracy for IBD2−61
Shah et al562USA (1995–98)Review of patient data168 PatientsUse of colonoscopy and biopsy2−61
Erickson and Glick563International (studies between 1974 and 1982 taken)Review of evidenceAround 80 articlesBenefits of oesophagogastroduodenoscopy2−61
Drossman et al551USA (1996–98)Survey of patients211 PatientsFactors pointing to the severity of functional bowel disorders2−70
Sands et al552USA (patients between 1991 and 1997)Analysis of patient data345 PatientsRisk of early surgery for Crohn’s disease2+64
Lang et al566Finland (1996–97)Observational study503 PatientsResource use in gastroenterological surgery2−70
Tunaci558International (2002)CommentaryNAImaging of GI cancers352
Quine et al867UK (1991)Audit15 Hospitals in East Anglia and northwest EnglandAudit of upper GI endoscopy2−59
Parry et al564UK (not specified—circa 2001)Retrospective study of patient data52 PatientsPush enteroscopy2−61
Diamanti et al550Italy (not specified—circa 2002)Analysis of patient data6 PatientsPatients with ultra-short bowel disease2−52
Yasui et al565International (cancer cases between 1993 and 1998)Analysis of cancer cases9241 CasesMolecular-pathological diagnosis of GI tissues for cancer histopathology2−68
Schofield567UK (data between 1994 and 1998 taken)Review of medical cases245 CasesMedical negligence in coloproctology357
Hansen et al547Denmark (1991–92)Interview of patients612 PatientsManagement of dyspeptic patients in primary care2−70
Talley et al546International (1991)Review of evidenceAround 180 articlesClassification and guidelines for the diagnosis and management of functional dyspepsia380
Mulcahy et al868UK (data between 1989 and 1998 taken)Retrospective review of patients data9795 PatientsPatterns of sedation use for diagnostic gastroscopy2−55
Hin et al378UK (1996–97)Case finding study30 PatientsCoeliac disease in primary care2−66
Schmulson and Chang542International (1999)Review of evidenceAround 50 articlesDiagnostic approach to IBS370
Martin et al555UK (1994)Analysis of patient data; survey115 PatientsDelays in the diagnosis of oesophagogastric cancer2−61
Angelelli et al553International (2003)Review of evidence; commentaryAround 40 articlesComputed tomography and acute bowel ischaemia366
Berg et al538International (2001)Review of evidence; commentaryAround 40 articlesAcute surgical emergencies in IBD364
Rockey et al869USA (2000–04)Comparison of imaging tests614 PatientsComparison of colon imaging tests2+82
Halligan and Atkin870UK (2005)CommentaryNAVirtual colonoscopy455
Section 4.7.1 Guidelines for care
Chiang et al797Australia (2001)Analysis of patient data167 PatientsAcute pancreatitis management2+68
BSG574UK (2002)GuidelinesNAGuidelines for dyspepsia managementGuideline45
Hamilton and Sharp556UK (evidence between 1966 and 2002 taken)Assessment of clinical guidelinesAround 100 articlesGuidelines for the diagnosis of colorectal cancer2+66
Association of Coloproctology of GB and Ireland505UK (2001)Specification of guidelinesNAGuidelines for the management of colorectal cancerGuideline61
Flashman et al507UK (2000–01)Audit249 PatientsTwo week standard for bowel cancer2−61
Kubba and Whyman606UK (1994)Survey of clinicians81 ResponsesSurvey of practice amongst Scottish gastroenterologists2−59
DoH605UK (2004)GuidelinesNARenal services implementation strategyGuideline45
Rockall et al398UK (1993)Analysis of patient data2531 PatientsManagement of upper GI haemorrhage2−57
Limburg and Ahlquist569International; emphasis on USA (2002)CommentaryNAManagement of colorectal cancer445
Ahmed et al571International (studies from 1996 onwards)Systematic reviewFour RCTsSupportive care for patients with GI cancer175
McNamara et al581International; emphasis on USA (2000)Review of evidence; expert commentaryAround 70 articlesNon-ulcer dyspepsia (NUD)2−64
Meineche-Schmidt871Denmark (1999–2000)RCT and follow-up829 PatientsHealthcare consumption2+57
Wexner et al600USA (2001)Commentary; consensusNAPrinciples for privileging and credentialing for endoscopy and colonoscopy452
Bardou et al572USA (1999–2002)Case-control studyOver 80 000 patientsTreatment of oesophageal cancer2+70
Bodger et al596UK (not specified—circa 1996)Analysis of physicians’ practice data9 GPsPrescriptions in primary care2−66
Delaney et al579International (2003)Systematic review20 RCTsManagement strategies for dyspepsia182
Fisher et al599USA (1995–1996)Analysis of patient data3546 PatientsMortality and follow-up colonoscopy after colorectal cancer2+61
Moum585International (2000)Review of evidenceAround 80 articlesMedical treatment for IBD364
Feuer595International (1999)Commentary; review of evidenceAround 20 articlesManagement of intestinal obstruction350
Conio et al591International (2001)Commentary; review of evidenceAround 80 articlesEndoscopic treatment of pancreatico-biliary malignancies357
Talley et al546International (1991)Review of evidenceAround 180 articlesClassification and guidelines for the diagnosis and management of functional dyspepsia380
Drossman et al551International (not specified—circa 1994)Survey of patients270 PatientsMeasuring health status and severity of illness for functional bowel disorders2−77
Jeffery et al568International (studies from 1966 onwards)Systematic review5 RCTsFollow-up strategies for colorectal cancer175
Axon et al602UK (not specified—circa 1995)Audit; survey of clinicians350 General physicians, 400 surgeons, 477 gastroenterologists, 70 GPsGuidelines on appropriate indications for upper GI endoscopy2+77
Allum et al570UK (2002)Review of evidence; recommendationsAround 340 articlesGuidelines for the management of oesophageal and gastric cancerGuideline75
Raine et al593UK (2002)Qualitative research into GPs’ beliefs46 GPsGPs’ perceptions of chronic disease syndrome and IBS2−73
Carter et al584UK (2004)Review of evidence; recommendationsAround 150 articlesGuidelines for the management of IBDGuideline75
Ryder594UK (2003)Review of evidence; recommendationsAround 150 articlesGuidelines for the diagnosis and treatment of hepatocellular carcinomaGuideline75
Verma and Giaffer588UK (not specified—circa 2001)Survey of patients; analysis of patient dataAround 1000 patientsH pylori eradication2−77
Milne et al872UK (1993)Survey of gastroenterologists670 Survey responsesH pylori and upper GI disease2−64
Parry et al578UK (1995)Survey of GPs140 GPsGPs’ management of dyspepsia in primary care2−73
Probert et al604UK (not specified—circa 1993)Survey of gastroenterologists236 Survey responsesGastroenterologists’ care profile for patients with IBD2−61
Whitaker et al589UK (1997)Commentary; review of guidelines for careAround 50 articlesManagement of GI disease in primary care359
Paton590UK (1992–93)Economic analysis; RCT255 PatientsComparison of two treatments for gastro-oesophageal reflux disease2+64
Wright et al586UK (not specified—circa 2001)Analysis of patient data6037 PatientsImplementation of H pylori eradication therapy2−61
NICE577UK (2003)GuidelinesNAManaging adult patients with dyspepsiaGuideline57
Spiegel et al575International; emphasis on USA (2002)Review of guidelines; economic modellingAround 120 articlesCompeting strategies for dyspepsia management2−75
Bodger et al576UK (1995–1996)Observational study340 PatientsImplications of BSG dyspepsia guidelines2−68
Association of coloproctology of GB and Ireland505UK (1999)Guidelines for coloproctologyNAGuidelines for coloproctologyGuideline45
Manes et al601Italy (1998)Analysis of patient data706 PatientsAppropriateness and diagnostic yield of upper GI endoscopy in an open access system2−64
Tremaine et al583USA (1997)Survey and analysis of patient dataNot clear—around 100 patientsPractice guidelines in IBD2+61
Section 4.7.2 Incidence of cancer
Forman et al873UK (data up to 1992; published 2003)Analysis of dataOver 1.5 million casesCancer prevalence in the UK2−66
Munkholm814International (2003)Review of evidence; commentaryAround 25 articlesIncidence and prevalence of colorectal cancer357
AGA788USA (2001)Review of evidence; expert commentaryOver 125 articlesPrevalence and costs of GI diseases2+68
Sant et al874Europe (2001)Analysis of routine data1 836 287 Patient recordsCancer survival rates2−57
Stanley et al816International (1988)Review of trendsAround 20 articlesMortality trends2−59
Askling et al875Sweden (data between 1952 and 1995 taken)Analysis of patient data114 102 RecordsColorectal cancer rates2+52
Lynch and de la Chapelle876International; emphasis on USA (2003)Commentary; review of evidenceAround 100 articlesHereditary colorectal cancer352
ONS441UK (data between 1991 and 2001)Update on cancer survival ratesNACancer survival ratesNANA
Sharp et al824UK (data between 1968 and 1992)Analysis of cancer dataNot specified, but a large amountCancer incidence and mortality2−50
McKinney et al835UK (data between 1960 and 1990)Analysis of cancer dataNot specified, but a large amountOesophageal and gastric cancer incidence2−52
Pye et al825UK (1995–96)Analysis of patient data910 PatientsCarcinoma of the oesophagus and stomach2−57
Bray et al328Europe (1995)Analysis of mortality dataNot specified, but a large amountCancer incidence and mortality2+66
Bardou et al572USA (1999–2002)Case-control studyOver 80 000 patientsTreatment of oesophageal cancer2+70
Rhodes and Campbell877International (2002)Review of evidenceAround 70 articlesInflammation and colorectal cancer361
AUGIS826UK (1999)Commentary and recommendationsNAService provision435
Section 4.7.4 Screening (includes surveillance)
Mpofu et al611International; emphasis on UK (2004)Systematic review9 Key reportsStrategies for detecting colon cancer184
Rozen et al608International (2002)Expert commentary; recommendationsNAWorldwide cancer screening373
Mandel et al609USA (longitudinal study—results from 70s, 80s, and 90s)Analysis of patient data46 551 ParticipantsScreening for colorectal cancer2+64
Garvican607UK (1998)Commentary; cost analysisNAColorectal cancer screening370
Doria-Rose et al633USA (data between 1994 and 2000 taken)Analysis of patient dataOver 70 000 participantsScreening intervals2−70
Lin et al613USA (1999)Survey of clinical practice103 ResponsesCurrent practices in Barrett’s oesophagus2−73
UK Colorectal Cancer Screening Pilot Group610UK (2000–03)Pilot/audit271 646 ParticipantsScreening for colorectal cancer2−64
Hill et al628UK (not specified—circa 2000)Assessment of practice109 FamiliesScreening for colorectal cancer2−57
Kronborg627Europe (1992)Assessment of guidelinesAround 50 articlesScreening guidelines for colorectal cancer2−68
Dubinsky et al623USA (2000)Economic and statistical analysesNot specifiedEconomic issues for competing diagnostic strategies2−75
Gerson et al615USA (2003)Economic modellingNot specified, but a large amountCost effectiveness of endoscopic screening and surveillance for GERD2−73
Lewis878USA (2000)CommentaryNAScreening of colorectal cancer443
Macafee and Scholefield632UK (2002)Commentary; review of evidenceAround 40 articlesScreening of colorectal cancer357
Ganz et al626USA (1999)Survey; RCT36 Provider organisationsScreening of colorectal cancer2+68
Gross et al612USA (1998)Survey of gastroenterologists279 Survey responsesManagement of Barrett’s oesophagus2−80
Loeve et al621USA (circa 2000—projected data between 1993 and 2023)Data simulationBaseline data from routine sources and expert opinionColorectal cancer screening2−77
Rae630Australia (data between 1987 and 1996 taken)Analysis of patient data3845 PatientsCommunity screening for colorectal cancer2−61
Nietert et al620USA (circa 2002)Economic modellingNACost effectiveness of screening for chronic gastroesophageal refulx disease2−75
Ramsey et al617USA (data between 1993 and 1999 taken)Analysis of patient data206 PatientsCosts of screening for colorectal cancer2−70
Sonnenberg et al879USA (1998)Economic modellingNACosts of screening for colorectal cancer2−70
Renehan et al618UK (2002)Review of evidence5 RCTsCost effectiveness of surveillance for colorectal cancer2+80
Helm et al625International; emphasis on USA (not specified—circa 2003)Review of evidence; commentaryAround 60 articlesStrategies for colorectal cancer screening380
Taylor et al629UK (not specified—circa 2000)Survey of patients4153 Survey responsesAcceptability of flexible sigmoidoscopy screening2−64
Bejes and Marvel624USA (not specified—circa 1992)Case-control study546 PatientsOffering colorectal cancer screening to patients2−61
Cotton et al635USA (2000–01)Non-randomised trial615 PatientsVirtual colonoscopy2−64
Hur et al634USA (2004)Mathematical modellingData from 1998 to 2002Computed tomographic colonography2−70
Section 4.7.5 Genetics
Lynch and de la Chapelle876International; emphasis on USA (2003)Commentary; review of evidenceAround 100 articlesHereditary colorectal cancer352
Polito II et al880USA (data between 1985 and 1991)Analysis of patient data552 PatientsGenetic anticipation in Crohn’s disease2−55
Yasui et al565International (cancer cases between 1993 and 1998)Analysis of cancer cases9241 CasesMolecular-pathological diagnosis of GI tissues for cancer histopathology2−68
Morris-Yates et al881Australia (participants between 1984 and 1986)Structured interviews of patients; genetic modelling686 Individual twinsGenetic contribution to functional bowel disorders2−70
Faybush et al882Canada (patient data between 1984 and 1995)Analysis of patient data315 PatientsGenerational differences in IBD: genetic, bias, and temporal effects issues2−59
Section 4.7.6 Prevention
Chan and Graham512International (2004)Review of evidenceAround 60 articlesPrevention of NSAID GI complications373
Muller and Sonnenberg652USA (1988–93)Analysis of patient dataOver 16 000 patientsPrevention of colorectal cancer2+55
Hulscher et al651International (review of studies from 1966 onwards)Systematic review55 StudiesPrevention in primary care177
O’Connor and Sebastian654Europe (2003)Review of evidence; commentaryAround 60 articlesBurden of H pylori in Europe350
Section 4.7.6 Devolution
Greer883UK (2004)Commentary; review of evidenceAround 30 articlesDevolution and the NHS352
Section 4.7.7 Managed cancer networks
CSCG808UK (2003)CommentaryNAResponse to NICE service guidance on upper GI cancersGuideline41
South Wales Cancer Network754UK (2003)Service guidelines; recommendationsNAConfiguration of services345
Section 4.7.8 Quality assessment
Garvican607UK (1998)Commentary; cost analysisNAColorectal cancer screening370
Association of Coloproctology of GB and Ireland505UK (2001)Specification of guidelinesNAGuidelines for the management of colorectal cancerGuideline61
Lilford et al884UK (not specified—circa 2004)Review of evidenceAround 90 articlesManaging performance in acute medical care373
Rockall et al885UK (1993–94)Collection and analysis of patient dataOver 5000 casesOutcomes after acute upper GI haemorrhage2−57
Johansen et al886USA (applicable internationally) (2000)CommentaryNAQuality and outcomes assessment in GI endoscopy345
Dougall et al887UK (1997)Survey of patients84 PatientsPatient experiences of an open access flexible sigmoidoscopy service2−77
Feuer and Broadley888International (studies from 1966 onwards)Systematic review25 ArticlesSurgery for malignant bowel obstruction in GI cancers2+73
Fletcher889Australia (1997)Review of evidenceAround 40 articlesManagement of peptic disease364
Bodenheimer et al890USA (2002)Case studyFour healthcare organisationsImproving primary care for chronic illness361
van der Eijk et al891International (2000)Literature reviewAround 80 articlesQuality of care in IBD368
Gilmore et al892UK (1991)Audit1500 Completed audit formsAudit of liver biopsy2−61
Jones809International (1999)Review of evidenceAround 20 articlesMethodological considerations368
McCulloch et al829UK (1999–2002)Cohort study; analysis of patient data955 PatientsMortality and morbidity in gastro-oesophageal cancer surgery2−64
Kurlberg et al893Sweden (2004)CommentaryNAAccess to patient information343
Bass et al695UK (1994)Analysis of patient data762 PatientsFrequent attendants at a gastroenterology clinic2−61
Palmer and Morris894UK (2004)CommentaryNAColonoscopy practice in England441
Bowles et al752UK (not specified—circa 2003)Survey of clinicians and patients9223 CasesColonoscopy practice in the UK2−66
Macarthur et al895UK (1993)Audit of deaths from large bowel surgery187 CasesDeaths from large bowel surgery2−61
van der Eijk et al896International (1998)Observational study/surveyPhysicians and health workers from 8 countriesBest practice in IBD2−73
Eaden et al897UK (not specified—circa 1998)Survey of clinicians341 ResponsesScreening for colonic cancer by gastroenterologists2−64
Section 5.1 Where should services be provided (primary, secondary, tertiary—includes patient roles)?
Scott et al898Canada (not specified—circa 2003)Survey of patients14 PatientsUse of complementary therapies for IBD2−55
Hinton899UK (not specified—circa 1994)Survey415 Patients; focus on 77 of theseTransfer of care from home to hospital2−45
Shepperd and Iliffe689International (1996–2001)Systematic review16 TrialsHospital versus home care166
Barrett et al900UK (1998–99)Retrospective study; analysis of routine data903 PatientsDescription of intermediate care service2−57
Gill and Martin901New Zealand (1995–97)Analysis of patient data3351 PatientsDistance from hospital2−59
South Wales Cancer Network754UK (2003)Service guidelines; recommendationsNAConfiguration of services345
Whynes and Thornton902UK (not specified—circa 1998)Economic/statistical analysisNot clear—data for around 18 wardsConcentration in primary care2−61
Section 5.2 What types of services should be provided (includes current provision)?
Gonsalkorale et al903UK (not specified—circa 2002)Survey of patients232 PatientsHypnotherapy in IBS2−75
van Dam et al904Not specified—probably international (not specified—circa 2004)Review of clinical trialsReview of around 10 papersReview of computerised tomographic colonography (CTC)2+70
Podolsky905Not specified—probably international (2004)Expert commentaryNACTC441
Silcock and Bramble502UK (1994)Survey333 ResponsesSurvey of current practice in open access gastroscopy (OAG)2−68
Baron et al906USA (2002–03)Cohort study498 PatientsDemand for colonoscopy2+66
Cheung et al907UK (1999)Survey and structured interviews160 GPsShared care in gastroenterology2−61
Moody et al772UK (not specified—circa 1993)Survey of GPs259 ResponsesGPs views on requirements for gastroenterology services2−70
Smith et al908UK (not specified—circa 2000)Survey of patients100 ResponsesImpact of a nurse-led counselling service2−68
Ilnyckyj et al909Canada (1996–1997)Observational study70 PatientsGastroenterology consultation2−64
Pasricha910Not specified—probably international (2004)Expert commentaryNAFuture of therapeutic endoscopy352
Axon911UK (1998)Expert commentaryNAOpen access endoscopy in Britain450
DoH912UK (2001)National commentary; recommendationsNAUpper GI cancersGuideline48
Richards et al760International (1997)Systematic review256 StudiesHome parenteral nutrition (HPN)177
Talley and Spiller913International (not specified—circa 2002)Review of evidenceAround 140 studiesIBS370
Nord914USA (1999)Expert commentaryNADevelopments in Endoscopy457
Jones770UK (1996)Expert commentaryNAGI disease in primary care359
van der Eijk et al896International (1998)Observational study/surveyPhysicians and health workers from 8 countriesBest practice in IBD2−73
Abuksis et al915Israel (1998)RCT142 PatientsA patient education programme2+68
Lewin van den Broek et al916Netherlands (1995–97)RCT349 PatientsManagement strategies for dyspepsia2+66
Delaney and Moayyedi917Predominantly UK (not specified—circa 2003)Evidence-based assessmentAround 160 articlesDyspepsia management2−57
Heaney et al918UK (1993–96)Analysis of patient and GP data1872 CasesOpen access gastroscopy in Royal Victoria Hospital, Belfast2−55
Pye et al825UK (1995–96)Analysis of patient data910 PatientsCarcinoma of the oesophagus and stomach2−57
Association of Coloproctology of GB and Ireland505UK (2001)Specification of guidelinesNAGuidelines for the management of colorectal cancerGuideline61
Hansen et al919Denmark (1987–88)Survey of patients and GPs436 PatientsEfficacy of open access endoscopy2−68
Section 5.3 Who should deliver/perform services and/or procedures (for example, endoscopies)?
Eaden et al897UK (not specified—circa 1998)Survey of clinicians341 ResponsesScreening for colonic cancer by gastroenterologists2−64
Paisley et al920UK (1994–96)Analysis of patient data222 PatientsRole of the surgical trainee2−59
Chin and Newton921UK (not specified—circa 1996)Survey167 Surgical traineesTraining in minimal access surgery2−66
Pardo et al922Spain (1998–99)Retrospective study; analysis of patient data620 PatientsImpact of physician speciality2−61
Waye et al923International (2001)Expert commentaryNAWho is permitted to do endoscopy?436
Bini et al924USA (1998–99)Analysis of routine data197 PatientsImpact of specialists2−68
Eaden et al925UK (data between 1985 and 1999 taken)Survey of clinicians13 CliniciansVariation between generals and specialists2−68
Barrison et al926UK (2001)Expert commentary and recommendationsNAProvision of endoscopy services in general hospitals445
Quine et al521UK (1991)Survey of clinicians39 Hospitals; 383 cliniciansAudit of upper GI endoscopy2−64
NHS CRD560UK (2004)National commentary; guidelines; recommendationsNAImproving the outcomes in colorectal cancerGuideline70
Lim et al927UK (1995)Survey of clinicians453 ResponsesH pylori serology and management2−68
Cockel et al928UK (1976–79)Survey173 ResponsesGI endoscopy services2−66
Meyer et al710USA (1993)Analysis of patient dataOver 1.3 million casesDifferences between generalists and specialists2−68
Knight-Davis et al929UK (1996)Survey of clinicians350 ResponsesCross-cover for physicians2−59
Association of Coloproctology of GB and Ireland753UK (2001)Analysis of audit data; expert commentary; recommendations8 Main sources of audit dataResources for coloproctology352
Chen and Rex717International (2004)Commentary; recommendationsNANurse administered sedation for endoscopy359
Nightingale and Hogg930UK (2003)Review of evidence; commentaryAround 40 articlesGI advanced practitioners364
Section 5.4 What are the key issues concerning changing roles and general practitioners with a special interest (GPwSI)?
Farthing et al931UK (1993)Peer reviewed expert commentary and recommendationsNAService provision359
Colin-Thome932UK, NHS (2002)CommentaryNAGPwSI443
Birch933UK, NHS (2004)Commentary; guidelinesNAGPwSI352
AUGIS826UK (1999)Commentary; recommendationsNAService provision435
Pearson et al934Boston, USA (1996)Survey of general internists and gastroenterologists91 Survey responsesStudy of consultations provided to general internists by gastroenterologists.2−75
Williams et al935UK (2002)Commentary; recommendationsNAThe role of GPwSI366
DoH and RCGP691UK (2003)Commentary; recommendationsNAImplementing GPwSIGuideline45
DoH and RCGP936UK (2002)National guidelinesNAGPwSI rolesGuideline25
Ryan937UK (2002)CommentaryNARole of GPwSI in respiratory disease430
Gruffydd-Jones938UK (2003)Brief commentaryNAFramework for GPwSI355
Kernick939UK (2003)CommentaryNAEconomic perspectives on GPwSI452
Richardson940UK (2002)Commentary; interviewsNARise of GPwSI450