Table 2 Biological parameters in relapsers versus non-relapsers (means) and univariate HR of relapse
RelapsersNon-relapsers
nMean* (SD)nMean† (SD)HR (95% CI)‡p Value
Biological
    CRP (mg/l)2912.1 (13.5)508.9 (14.1)1.2 (0.97 to 1.5)§0.08
    CRP ⩾10 mg/l2913*5010*2.6 (1.2 to 5.6)0.01
    ESR (mm/h)2624.2 (13.9)5019.1 (14.2)1.3 (1.0 to 1.7)§0.05
    IL1β (pg/ml)2915.2 (19.6)4917.3 (50.3)1.0 (0.99 to 1.0)0.93
    sIL2R (U/ml)2950.9 (15.2)4949.0 (20.4)1.1 (0.92 to 1.2)§0.43
    IL6 (pg/ml)294.5 (4.9)493.0 (3.1)1.0 (0.96 to 1.1)0.73
    IL10 (pg/ml)2958.5 (37.0)4943.7 (37.3)1.0 (0.9 to 1.1)§0.94
    TNF (pg/ml)2940.9 (37.1)4955.0 (66.0)1.0 (0.94 to 1.1)§0.83
    ASCA+2917¶5026¶1.2 (0.54 to 2.5)0.70
    Lac/Man**290.024 (0.012)490.022 (0.016)1.1 (0.85 to 1.4)††0.50
    Lac/Man >0.03294911¶1.6 (0.74 to 3.7)0.22
Psychosocial
    Hassles Scale2633.2 (19.1)4325.2 (18.0)1.05 (0.95 to 1.15)0.36
    Perceived stress‡‡2616.9 (6.1)4213.7 (6.8)1.2 (0.9 to 1.6)§§0.19
    Coping inventory¶¶
        Avoidance2636.3 (11.9)4333.4 (11.6)1.0 (0.85 to 1.2)¶¶0.88
        Emotional2636.7 (10.4)4331.1 (10.6)1.15 (0.97 to 1.4)¶¶0.11
        Task-oriented2646.7 (10.5)4348.2 (13.4)0.90 (0.78 to 1.04)¶¶0.17
    SCL-90R
        GSI (raw)260.59 (0.51)430.44 (0.46)1.7 (0.77 to 3.7)0.19
        Depression (raw)260.86 (0.76)430.57 (0.50)1.6, (0.9 to 2.7)0.10
        Anxiety (raw)260.58 (0.62)430.43 (0.56)1.4 (0.77 to 2.6)0.25
  • *Mean of all values for that variable on the visit prior to relapse. †Mean value at 6 months. ‡HR determined by univariate Cox regression using measures 14–92 days prior to relapse for biological markers and 14–35 days for psychosocial variables. §HR per increase of 10 units. ¶Number of individuals with the indicated outcome. **Lactulose/mannitol ratio. ††HR per increase of 0.001 units. ‡‡Perceived Stress Scale. §§HR per increase of 5 units. ¶¶Coping Inventory for Stressful Situations.

  • ASCA, anti-Saccharomyces cerevisiae antibody; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; GSI, Global Severity Index; IL, interleukin; SCL-90R, Symptom Checklist 90-R; sIL2R, soluble interleukin 2 receptor; TNF, tumour necrosis factor.