| Oesophageal adenocarcinoma | Gastro-oesophageal junction adenocarcinoma | |||||
| Controls/Cases | Fully adjusted, except reflux* | Fully adjusted, with reflux† | Cases | Fully adjusted, except reflux† | Fully adjusted, with reflux | |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |||
| BMI last year (kg/m2) | ||||||
| <18.5 | 21/1 | 0.3 (0.0 to 2.6) | 0.5 (0.1 to 3.6) | 1 | 0.2 (0.0 to 1.7) | 0.3 (0.0 to 2.0) |
| 18.5–24.9 | 528/71 | 1.0 (ref) | 1.0 (ref) | 107 | 1.0 (ref) | 1.0 (ref) |
| 25.0–29.9 | 650/150 | 1.4 (1.0 to 1.9) | 1.2 (0.9 to 1.7) | 168 | 1.1 (0.8 to 1.4) | 1.0 (0.7 to 1.3) |
| 30.0–34.9 | 222/89 | 2.7 (1.8 to 3.9) | 2.1 (1.4 to 3.1) | 98 | 1.9 (1.3 to 2.6) | 1.6 (1.1 to 2.2) |
| 35.0–39.9 | 68/25 | 3.1 (1.8 to 5.5) | 2.5 (1.4 to 4.4) | 27 | 2.0 (1.2 to 3.4) | 1.7 (1.0 to 3.0) |
| 40+ | 24/16 | 7.0 (3.3 to 15.0) | 6.1 (2.7 to 13.6) | 9 | 2.6 (1.1 to 6.2) | 2.4 (1.0 to 5.8) |
| p trend | <0.001 | <0.001 | <0.001 | <0.001 | ||
| BMI maximum (kg/m2) | ||||||
| <18.5 | 9/1 | 0.9 (0.1 to 8.7) | 1.4 (0.2 to 11.9) | 0 | – | – |
| 18.5–24.9 | 356/39 | 1.0 (ref) | 1.0 (ref) | 55 | 1.0 (ref) | 1.0 (ref) |
| 25.0–29.9 | 708/136 | 1.4 (0.9 to 2.0) | 1.2 (0.8 to 1.7) | 178 | 1.3 (0.9 to 1.8) | 1.1 (0.8 to 1.6) |
| 30.0–34.9 | 333/114 | 2.5 (1.6 to 3.7) | 1.9 (1.3 to 3.0) | 122 | 1.9 (1.3 to 2.7) | 1.6 (1.1 to 2.4) |
| 35.0–39.9 | 107/43 | 4.1 (2.4 to 6.8) | 3.1 (1.8 to 5.3) | 47 | 2.9 (1.8 to 4.6) | 2.4 (1.5 to 3.9) |
| 40+ | 52/24 | 5.2 (2.7 to 9.9) | 4.4 (2.3 to 8.7) | 15 | 2.1 (1.1 to 4.2) | 1.9 (1.0 to 3.8) |
| p trend | <0.001 | <0.001 | <0.001 | <0.001 | ||
| BMI age 20 years (kg/m2) | ||||||
| <18.5 | 121/14 | 0.8 (0.4 to 1.4) | 0.8 (0.5 to 1.6) | 9 | 0.4 (0.2 to 0.8) | 0.4 (0.2 to 0.8) |
| 18.5–24.9 | 1144/227 | 1.0 (ref) | 1.0 (ref) | 282 | 1.0 (ref) | 1.0 (ref) |
| 25.0–29.9 | 237/81 | 1.7 (1.2 to 2.3) | 1.7 (1.2 to 2.3) | 97 | 1.6 (1.2 to 2.1) | 1.6 (1.2 to 2.2) |
| 30.0–34.9 | 29/13 | 2.6 (1.3 to 5.2) | 2.4 (1.1 to 5.1) | 13 | 2.1 (1.0 to 4.1) | 2.0 (0.9 to 4.1) |
| 35.0+ | 6/5 | 3.6 (1.0 to 13.0) | 2.9 (0.8 to 11.2) | 2 | 1.1 (0.2 to 5.9) | 1.0 (0.2 to 5.3) |
| p trend | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Change in BMI (kg/m2) | ||||||
| <3 | 581/98 | 1.0 (ref) | 1.0 (ref) | 131 | 1.0 (ref) | 1.0 (ref) |
| 3–4.9 | 338/73 | 1.2 (0.9 to 1.7) | 1.0 (0.7 to 1.5) | 96 | 1.1 (0.8 to 1.6) | 1.0 (0.7 to 1.4) |
| 5–9.9 | 406/117 | 1.7 (1.3 to 2.4) | 1.4 (1.0 to 2.0) | 115 | 1.2 (0.9 to 1.6) | 1.1 (0.8 to 1.5) |
| 10+ | 153/47 | 2.2 (1.4 to 3.4) | 1.8 (1.2 to 2.8) | 50 | 1.6 (1.0 to 2.3) | 1.4 (0.9 to 2.1) |
| p trend | <0.001 | 0.002 | 0.05 | 0.26 | ||
*Adjusted for age, sex, state, household income, cumulative smoking history, mean alcohol consumption and frequency of aspirin use in the 5 years before diagnosis.
†Adjusted for above factors and frequency of gastro-oesophageal reflux symptoms 10 years before diagnosis.