Table 3 Relationship between risk of oesophageal adenocarcinoma and pepsinogen I/II, smoking, GORD symptoms and H pylori sero-status
UnivariateMultivariate
Odds ratio (95% CI)p valueOdds ratio (95% CI)p value
PG ratio quintiles
    5th: 4.482–9.4091.001.00
    4th: 3.395–4.2660.35 (0.07 to 1.72)0.1970.40 (0.05 to 3.29)0.397
    3rd: 2.611–3.2710.35 (0.07 to 1.72)0.1970.26 (0.03 to 2.22)0.217
    2nd: 1.978–2.4830.29 (0.06 to 1.46)0.1320.57 (0.08 to 4.11)0.573
    1st: 1.155–1.9590.26 (0.05 to 1.49)0.1310.41 (0.05 to 3.69)0.427
Smoking
    Non-smoker1.001.00
    Ever smoker4.70 (1.54 to 14.34)0.0074.56 (1.01 to 20.68)0.049
GORD symptoms
    <1 time per week1.001.00
    1–2 times per week2.60 (0.65 to 10.36)0.1751.73 (0.33 to 9.11)0.520
    >2 more times per week28.05 (4.74 to 165.91)0.00112.46 (1.80 to 86.47)0.011
H pylori sero-status
    Negative1.001.00
    Positive0.25 (0.08 to 0.75)0.0140.43 (0.10 to 1.91)0.268