Table 4 Relationship between risk of gastric cardia cancer and pepsinogen I/II, smoking, GORD symptoms and H pylori sero-status
UnivariateMultivariate
Odds ratio (95% CI)p valueOdds ratio (95% CI)p value
PG ratio quintiles
    5th: 6.008–11.5861.001.00
    4th: 3.848–6.0041.10 (0.50 to 2.40)0.8170.92 (0.37 to 2.26)0.852
    3rd: 3.062–3.7340.50 (0.20 to 1.25)0.1380.62 (0.23 to 1.71)0.355
    2nd: 2.378–3.0170.50 (0.20 to 1.25)0.1380.49 (0.18 to 1.38)0.177
    1st: 0.479–2.3702.77 (1.36 to 5.63)0.0053.92 (1.77 to 8.67)0.001
Smoking
    Non-smoker1.001.00
    Ever smoker1.70 (0.79 to 3.67)0.1751.40 (0.56 to 3.51)0.476
GORD symptoms
    <1 time per week1.001.00
    1–2 times per week0.95 (0.40 to 2.29)0.9151.47 (0.54 to 4.00)0.451
    >2 more times per week3.15 (1.17 to 8.49)0.02410.08 (2.29 to 44.36)0.002
H pylori sero-status
    Negative1.001.00
    Positive1.46 (0.68 to 3.14)0.3322.42 (0.84 to 7.02)0.103