Table 7 Supervised class prediction of NR and SVR using gene expression profiles
Best selected modelNR predictive accuracySVR predictive accuracyOverall predictive accuracy
k-nearest neighbour
    Group A (training set, n = 40)IFI27, CXCL9*57.1% (8/14)88.5% (23/26)77.5% (31/40)
    Group B (test set, n = 29)100% (9/9)70.0% (14/20)79.3% (23/29)
Weighted voting
    Group A (training set, n = 40)IFI27, CXCL9, IFI-6-16*64.3% (9/14)88.5% (23/26)80.0% (32/40)
    Group B (test set, n = 29)88.9% (8/9)65.0% (13/20)72.4% (21/29)

  • *p Value <0.005 (estimated using 200 randomly permuted data sets).

  • NR, non-responder; SVR, sustained virological responder.