Table 8 Performance of the two-gene signatures according to liver fibrosis stage
NR predictive accuracySVR predictive accuracyOverall predictive accuracy
Two-gene signature (IFI27, CXCL9)*
    Group F1–F2 (n = 48)69.2% (9/13)82.9% (29/35)79.2% (38/48)
    Group F3–F4 (n = 21)90.0% (9/10)81.8% (9/11)85.7% (18/21)
Three-gene signature (IFI27, CXCL9, IFI-6-16)*
    Group F1–F2 (n = 48)69.2% (9/13)88.6% (31/35)83.3% (40/48)
    Group F3–F4 (n = 21)60.0% (6/10)100% (11/11)81.0% (17/21)
  • *The predictive accuracy of the two-gene and of the three-gene signatures was evaluated using the k-nearest neighbour classifier and the weighted voting classifier, respectively.

  • NR, non-responder; SVR, sustained virological responder.