Characteristics | HCC (n = 132) (%) | Controls (n = 204) (%) | OR* (95% CI) |
Age (years) | |||
30–39 | 18 (13.6) | 28 (13.7) | |
40–49 | 54 (40.9) | 77 (37.7) | |
50–59 | 34 (25.8) | 55 (27.0) | |
⩾60 | 26 (19.7) | 44 (21.6) | |
ALT | |||
⩽ULN | 81 (61.8) | 170 (83.3) | 1 |
>ULN | 50 (38.2) | 34 (16.7) | 3.45 (2.03 to 5.88) |
HBV genotype | |||
A+B | 0 (0.0) | 1 (0.5) | 1 |
B | 63 (48.8) | 171 (84.2) | |
B+C | 1 (0.8) | 1 (0.5) | |
C | 65 (50.4) | 30 (14.8) | 5.85 (3.48 to 9.83) |
HBeAg | |||
Negative | 112 (85.5) | 183 (91.0) | 1 |
Positive | 19 (14.5) | 18 (9.0) | 1.73 (0.84 to 3.54) |
Anti-HBe | |||
Negative | 57 (43.5) | 32 (15.9) | 1 |
Positive | 74 (56.5) | 169 (84.1) | 0.22 (0.13 to 0.38) |
HBV DNA levels (log10 copies/ml) | |||
⩾3.87 and <4.23 | 7 (5.3) | 34 (16.7) | 1 |
⩾4.23 and <4.90 | 25 (18.9) | 56 (27.5) | 2.20 (0.86 to 5.65) |
⩾4.91 and <5.90 | 27 (20.5) | 58 (28.4) | 2.29 (0.90 to 5.84) |
⩾5.91 | 73 (55.3) | 56 (27.5) | 6.39 (2.63 to 15.51) |
OR, odds ratio; CI, confidence interval; ALT, alanine aminotransferase; ULN, upper limit of the normal range; HBV, hepatitis B virus; HBeAg, hepatitis B e antigen; anti-HBe, antibodies against HBeAg.
One case had missing ALT levels, four subjects (one case and three controls) had missing data on status of HBeAg and anti-HBe, and four subjects (three cases and one control) had missing genotype of HBV because their genotypes could not be determined.
*OR adjusted for age at recruitment (continuous variable) and date of blood collection (continuous variable).