| Region | Variant | HCC (n = 132) (%) | Controls (n = 204) (%) | OR† (95% CI) | |
| EnhII | nt 1703 | A | 109 (82.6) | 186 (91.2) | 1 |
| G | 20 (15.2) | 7 (3.4) | 2.21 (1.14 to 4.28) | ||
| C | 3 (2.2) | 11 (5.4) | |||
| nt 1719 | G | 104 (78.8) | 193 (94.6) | 1 | |
| T | 28 (21.2) | 11 (5.4) | 4.64 (2.21 to 9.71) | ||
| nt 1726 | C | 48 (36.4) | 128 (62.7) | 1 | |
| A | 83 (62.9) | 76 (37.3) | 2.94 (1.86 to 4.63) | ||
| G | 1 (0.7) | 0 (0.0) | |||
| nt 1727 | T | 56 (42.4) | 143 (70.1) | 1 | |
| A | 50 (37.9) | 35 (17.2) | 3.21 (2.03 to 5.08) | ||
| G | 23 (17.4) | 18 (8.8) | |||
| C | 3 (2.3) | 8 (3.9) | |||
| nt 1730 | G | 60 (45.5) | 155 (76.0) | 1 | |
| C | 71 (53.8) | 48 (23.5) | 3.82 (2.38 to 6.12) | ||
| A | 1 (0.7) | 1 (0.5) | |||
| EnhII/BCP | nt 1753 | T | 102 (77.3) | 181 (88.7) | 1 |
| C | 26 (19.7) | 16 (7.8) | 2.35 (1.29 to 4.30) | ||
| A | 2 (1.5) | 2 (1.0) | |||
| G | 2 (1.5) | 4 (2.0) | |||
| Frameshift | 0 (0) | 1 (0.5) | |||
| nt 1762 | A | 52 (39.4) | 132 (64.7) | 1 | |
| T | 77 (58.3) | 69 (33.8) | 2.90 (1.83 to 4.60) | ||
| Deletion/frameshift | 3 (2.3) | 3 (1.5) | |||
| nt 1764 | G | 48 (36.4) | 131 (64.2) | 1 | |
| A | 81 (61.4) | 69 (33.8) | 3.24 (2.04 to 5.16) | ||
| T | 0 (0) | 1 (0.5) | |||
| Deletion/frameshift | 3 (2.2) | 3 (1.5) | |||
| BCP | nt 1799 | G | 57 (43.2) | 152 (74.5) | 1 |
| C | 69 (52.3) | 48 (23.5) | 3.92 (2.45 to 6.26) | ||
| T | 2 (1.5) | 1 (0.5) | |||
| A | 1 (0.7) | 0 (0) | |||
| Frameshift | 3 (2.3) | 3 (1.5) | |||
| Precore | Without start/stop codon mutation | 55 (41.7) | 66 (32.4) | 1 | |
| Stop codon mutation | 69 (52.3) | 121 (59.3) | 0.67 (0.43 to 1.06) | ||
| Start codon mutation | 8 (6.0) | 17 (8.3) | |||
*For all nt positions in EnhII/BCP, the most prevalent nt type among controls were used as the reference group. For the precore region, subjects without the start/stop codon mutation were used as the reference group.
†OR adjusted for age at recruitment (continuous variable) and date of blood collection (continuous variable).
CI, confidence interval; nt, nucleotide; A, adenine; G, guanine; C, cytosine; T, thymine.