Table 3 Results of factor analysis with hepatitis B virus (HBV)-related variables and factor loadings*

Variable	Not including HBV viral load			Including HBV viral load
Variable	Factor 1	Factor 2	Factor 3	Factor 1	Factor 2	Factor 3	Factor 4
nt 1703 variants	0.6355	−0.4543	−0.0215	0.6472	−0.1756	−0.4041	−0.1848
nt 1719 variants	0.5856	0.0297	−0.0149	0.5894	0.2396	−0.0383	0.3147
nt 1726 variants	0.7750	0.1000	−0.1814	0.7740	0.1276	0.1180	−0.1229
nt 1727 variants	0.8817	0.1847	−0.1562	0.8855	0.0486	0.2131	−0.1260
nt 1730 variants	0.9176	0.1817	−0.1156	0.9160	0.0739	0.2010	−0.0620
nt 1753 variants	0.1587	0.7096	0.2098	0.1333	−0.1126	0.7269	0.1358
BCP double variants	0.2398	0.6969	−0.2462	0.2535	0.0708	0.7173	−0.1858
nt 1799 variants	0.8378	0.2230	−0.1864	0.8396	0.0924	0.2489	−0.1445
Precore start/stop codon mutation	−0.0875	0.1026	0.8006	−0.1343	−0.1504	0.0125	0.9117
Genotype C	0.7407	0.3086	−0.1519	0.7304	0.3234	0.2728	0.1156
Anti-HBe positivity	−0.1829	−0.0955	0.7162	−0.1943	−0.8054	−0.0201	0.1885
HBV viral load (log₁₀ copies/ml)				0.0587	0.8584	−0.0497	0.0201

*Excluding four subjects (one case and three controls) with missing data on anti-HBe status and four subjects (three cases and one control) for whom HBV genotype could not be determined. For all nt positions listed in the table, we assigned 1 to variants and 0 otherwise. For precore sequence variation, we assigned 1 to the precore start/stop codon mutation and 0 otherwise. The value of the BCP double variants was treated to be 0 when A1762 and G1764 were present and 1 otherwise. For anti-HBe status, we assigned 1 to positivity and 0 to negativity.
nt, nucleotide; BCP, basal core promoter; anti-HBe, antibodies against hepatitis B e antigen.