Table 5 Odds ratios (ORs) for hepatocellular carcinoma (HCC) associated with sequence variants of hepatitis B virus by lag time between baseline measurement and diagnosis*
VariableControls(n = 204)⩽3 years>3 and ⩽6 years>6 and ⩽9 years>9 years
HCC (n = 23)OR (95% CI)HCC (n = 32)OR (95% CI)HCC (n = 45)OR (95% CI)HCC (n = 32)OR (95% CI)
Genotype†
    Non-C17471191231151
    C291512.16 (4.50 to 32.86)123.73 (1.63 to 8.52)215.54 (2.70 to 11.36)176.36 (2.77 to 14.60)
Genotype C-related nucleotide variants‡
    Absence1103113116181
    Presence94208.19 (2.33 to 28.80)191.73 (0.81 to 3.69)292.23 (1.13 to 4.39)243.24 (1.36 to 7.70)
    No. of genotype C-related nucleotide variants‡ (mean)1.313.611.75§ (1.38 to 2.23)2.091.22§ (1.02 to 1.46)2.691.38§ (1.18 to 1.61)2.721.37§ (1.14 to 1.65)
BCP double variants
    Absence12921121161161
    Presence752116.48 (3.73 to 72.73)202.85 (1.31 to 6.18)293.06 (1.55 to 6.04)162.00 (0.91 to 4.39)
Precore stop/start codon mutation
    Absence66131111171141
    Presence138100.33 (0.13 to 0.81)210.91 (0.41 to 2.01)280.77 (0.39 to 1.52)180.70 (0.32 to 1.54)
  • *ORs were calculated with the use of all controls as the reference group and adjusted for age at recruitment (continuous variable) and date of blood collection (continuous variable).

  • †Four subjects (three cases and one control) for whom HBV genotype could not be determined were excluded from analysis.

  • ‡Variants at positions 1703, 1719, 1726, 1727, 1730 and 1799.

  • §OR of HCC with each additional genotype C-related variant.

  • CI, confidence interval; BCP, basal core promoter.