Table 4 Associations between fatigue, depression and histological findings according to irritable bowel syndrome subtype, controls and depressed patients

	Patients						IBS subtype
	IBS (n = 50)		Controls (n = 21)		Depressed (n = 11)		IBS-C (n = 29)		IBS-D (n = 21)
	FIS	BDI	FIS	BDI	FIS	BDI	FIS	BDI	FIS	BDI
Cellularity of lamina propria	r = 0.51	r = 0.002	r = 0.14	r = 0.002	r = −0.12	r = 0.09	r = 0.45	r = 0.01	r = 0.46	r = 0.02
Cellularity of lamina propria	p = 0.0001	p = 0.88	p = 0.27	p = 0.88	p = 0.72	p = 0.77	p = 0.01	p = 0.95	p = 0.01	p = 0.92
Mast cells	r = 0.64	r = 0.29	r = 0.15	r = 0.28	r = −0.21	r = 0.03	r = 0.61	r = 0.31	r = 0.61	r = 0.22
Mast cells	p = 0.0001	p = 0.03	p = 0.26	p = 0.07	p = 0.52	p = 0.91	p = 0.0004	p = 0.04	p = 0.0004	p = 0.32

BDI, Beck Depression Inventory; FIS, Fatigue Impact Scale; IBS, irritable bowel syndrome; IBS-C, IBS with constipation; IBS-D, IBS with diarrhoea.