Table 1 Characteristics of symptomatic and asymptomatic reflux episodes in 20 patients with persisting symptoms on proton pump inhibitors
All reflux episodesSymptomatic reflux episodesAsymptomatic reflux episodesp value*
Upright position (%)93.6 (81.7–98.0)100 (90–100)92.3 (81.0–95.7)0.209
Pure liquid reflux (%)53.1 (36.8–63.9)48.4 (21.7–72.9)56.3 (39.1–69.5)0.398
Proximal reflux events (%)38.3 (18.2–62.1)53.3 (20.0–78.1)33.8 (16.2–56.7)0.037
Reflux bolus clearance time (s)10.6 (9.6–12.7)10.5 (6.8–13.1)10.5 (9.4–20.4)0.852
Bolus burden (s)51.9 (24.2–115.8)59.9 (11.1–114.7)62.1 (25.9–110.0)0.654
Acid reflux (%)6.0 (1.6–20.0)0 (0– 15.8)7.4 (1.4–20.8)0.381
Nadir pH5.2 (4.8–5.9)5.4 (4.7–5.8)5.2 (4.8–5.9)0.344
Acid burden (s)0 (0–0)0 (0–0)0 (0–0)1.000
Acid clearance time (s)5.6 (1.5–20.0)3.1 (0.0–16.6)5.8 (0.7–20.3)0.500
Preceding acid reflux0 (0–0)0 (0–0.4)0 (0–0)0.102
Preceding weakly acidic reflux2.5 (1.1–4.0)2.5 (2.0–4.9)2.5 (1.1–4.0)0.795
  • Values are medians (interquartile range).

  • *Symptomatic versus asymptomatic: Wilcoxon signed rank test.