Table 3 Characteristics of reflux episodes associated with heartburn and regurgitation
Heartburn n (%)Regurgitation n (%)p value
Position<0.001
    Upright54 (71.1)236 (95.9)
    Supine22 (28.9)10 (4.1)
Composition0.009
    Liquid53 (69.7)130 (52.8)
    Mixed liquid–gas23 (30.3)116 (47.2)
Reflux0.027
    Acid24 (31.6)48 (19.5)
    Weakly acidic/weakly alkaline52 (68.4)198 (80.5)
Nadir pH*4.8 (3.7–5.5)5.5 (4.2–6.1)<0.001
Acid clearance time (s)*12 (0–34.5)17 (0–30)0.872
Acid burden (s)*0 (0–128.9)0 (0–0)<0.001
Preceding acid reflux (1 h)<0.001
    Yes37 (48.7)67 (27.2)
    No39 (51.3)179 (72.8)
Number of preceding acid refluxes*0 (0–5)0 (0–1)<0.001
Preceding weakly acidic reflux (1 h)0.860
    Yes70 (92.1)225 (91.5)
    No6 (7.9)21 (8.5)
Number of preceding weakly acidic refluxes*4 (3–8)5 (2–10)0.732
Reflux bolus clearance time (s)*16.3 (7.3–60.9)10.3 (5.7–20.9)<0.001
Bolus burden (s)*157.9 (51.8–445.2)117.6 (47.5–252)0.034
Proximal reflux events0.614
    Yes54 (71.1)182 (74.0)
    No22 (28.9)64 (26.0)
  • *Median (interquartile range).