| Analysis | HR (95% CI) | Significance | Heterogeneity (I2) | Total patients |
| Overall survival | 1.45 (1.35 to 1.55) | <0.001 | 10.3% | 10 126 |
| Progression-free survival (all patients) | 1.71 (1.51 to 1.94) | <0.001 | 22.4% | 4026 |
| Anatomical location | ||||
| Colon (all patients) | 1.67 (1.32 to 2.11) | <0.001 | 30.4% | 1213 |
| Rectum (all patients) | 1.63 (1.33 to 1.99) | <0.001 | 35.0% | 1073 |
| Stage | ||||
| Stage II | 1.68 (1.25 to 2.25) | 0.001 | 0% | 1179 |
| Stage III | 1.38 (1.14 to 1.67) | 0.001 | 1.4% | 1177 |
| Stage II–III (combined, all patients) | 1.45 (1.27 to 1.65) | <0.001 | 0% | 3094 |
| Adjuvant therapy | ||||
| Treatment (CIN vs diploid) | 1.85 (1.21 to 2.82) | 0.004 | 0% | 868 |
CIN, chromosomal instability.