Table 4 Comparison of pH and Bilitec measurements in gastro-oesophageal reflux disease patients with low and high grade oesophagitis, excluding Barrett’s oesophagus
OesophagitisGrade A, BGrade C, Dp Value
Number15113
Age45.5 (1.2)47.7 (4.8)NS
BMI25.8 (0.4)26.7 (1.1)NS
Smoking (%)29%35%NS
Alcohol use (%)28%33%NS
Helicobacter (%)13%8%NS
Hiatus hernia (%)52%59%NS
LOS pressure16.4 (0.7)10.8 (1.5)<0.01
Normal peristalsis82%89%NS
Total time acid reflux
No. of reflux episodes56 (22–100)95.5 (31–125.7)NS
Total reflux episodes >5 min1 (0–4)5.5 (0.3–8.5)<0.05
% pH<43.3 (0.95–8.2)10.6 (2.7–34.5)<0.05
Upright position acid reflux
No. of reflux episodes38 (15–78.5)85 (26–117.5)<0.05
Total reflux episodes >5 min0 (0–2)2.5 (0–6)<0.001
% pH<43.5 (0.9–8.6)11.7 (2.7–31.1)<0.001
Supine position acid reflux
Number of reflux episodes6 (0–24.5)6 (0.2–17.2)NS
Total reflux episodes >5 min0 (0–2)0.5 (0–3.0)NS
% pH<41.1 (0–8.7)6.9 (0–49.6)<0.001
Total time DGOR
No. of reflux episodes18 (6–47)41.5 (24.5–53.5)<0.05
Total reflux episodes >5 min3 (1–7)4.5 (3–7.8)NS
% bile absorbance >0.147.7 (1.6–25.3)12.6 (8.7–33.5)NS
Upright position DGOR
No. of reflux episodes13 (4.5–32)32 (21.5–41.8)<0.05
Total reflux episodes >5 min2 (1–5)3 (1.5–6.5)NS
% bile absorbance >0.148.6 (1.7–25.5)18.6 (5.7–28.8)NS
Supine position DGOR
No. of reflux episodes1 (0–11.5)3 (0.2–18)NS
Total reflux episodes >5 min0 (0–2.5)1.5 (0–4)NS
% bile absorbance >0.141 (0–25.7)12.7 (0–26.8)NS
  • The periods are subdivided into total time, upright and supine position. The values are given in means (SD) or mean (IQR) and compared with the Mann–Whitney test or χ2 test.

  • BMI, body mass index; DGOR, duodeno-gastro-oesophageal reflux; LOS, lower oesophageal sphincter; NS, not significant.