| Molecular feature | Total n | Colon cancer-specific mortality | Overall mortality | |||||
| Deaths per person-years | Univariate HR (95% CI) | Multivariate HR (95% CI) | Deaths per person-years | Univariate HR (95% CI) | Multivariate HR (95% CI) | |||
| MSI | MSS | 528 | 149/4653 | 1 (referent) | 1 (referent) | 238/4653 | 1 (referent) | 1 (referent) |
| MSI-high | 121 | 14/1101 | 0.38 (0.22 to 0.66) | 0.70 (0.36 to 1.37) | 43/1101 | 0.75 (0.54 to 1.04) | 0.89 (0.58 to 1.38) | |
| CIMP | CIMP-0 | 271 | 70/2556 | 1 (referent) | 1 (referent) | 106/2556 | 1 (referent) | 1 (referent) |
| CIMP-low | 252 | 66/2183 | 1.09 (0.78 to 1.53) | 0.78 (0.54 to 1.11) | 116/2183 | 1.27 (0.98 to 1.66) | 1.01 (0.77 to 1.33) | |
| CIMP-high | 126 | 27/1016 | 0.88 (0.57 to 1.38) | 0.44 (0.22 to 0.88) | 59/1016 | 1.35 (0.98 to 1.85) | 0.78 (0.47 to 1.29) | |
| KRAS mutation | (−) | 409 | 98/3604 | 1 (referent) | 1 (referent) | 170/3604 | 1 (referent) | 1 (referent) |
| (+) | 238 | 65/2137 | 1.10 (0.81 to 1.51) | 1.06 (0.73 to 1.54) | 111/2137 | 1.10 (0.86 to 1.40) | 0.98 (0.74 to 1.28) | |
| BRAF mutation | (−) | 526 | 127/4821 | 1 (referent) | 1 (referent) | 229/4821 | 1 (referent) | 1 (referent) |
| (+) | 105 | 36/775 | 1.73 (1.20 to 2.51) | 1.97 (1.13 to 3.42) | 52/775 | 1.46 (1.08 to 1.98) | 1.20 (0.79 to 1.80) | |
The multivariate analysis model includes age, year of diagnosis, sex, tumour location, stage, tumour grade, and statuses of MSI, CIMP, KRAS and BRAF.
CI confidence interval; CIMP, CpG island methylator phenotype; HR, hazard ratio; MSI, microsatellite instability; MSS, microsatellite stable.