Table 3 Stage-specific hazard ratio for colon cancer-specific mortality in CIMP-high tumours compared to CIMP-0 tumours
AJCC tumour stageTotal nMultivariate HR (with 95% CI)*
Stage I820†
Stage II1520.76 (0.20 to 2.82)
Stage III960.52 (0.17 to 1.59)
Stage IV430.47 (0.18 to 1.21)
Stage missing240†

  • The multivariate analysis model includes the CIMP variable (CIMP-high vs CIMP-0) stratified by stage, age, year of diagnosis, sex, tumour location, tumour stage, grade, MSI, CIMP, KRAS and BRAF.

  • *For colon cancer-specific mortality in CIMP-high tumours compared to CIMP-0 tumours.

  • †95% CI is not shown because there was no death in patients with stage I and stage-missing CIMP-high tumours.

  • AJCC, American Joint Commission on Cancer; CI confidence interval; CIMP, CpG island methylator phenotype; HR, hazard ratio.