| Molecular feature | n | Colon cancer-specific mortality | Overall mortality | ||
| Deaths per person-years | Multivariate HR (95% CI) | Deaths per person-years | Multivariate HR (95% CI) | ||
| MSS CIMP-low/0 | 490 | 134/4384 | 1 (referent) | 218/4384 | 1 (referent) |
| MSS CIMP-high | 38 | 15/269 | 0.40 (0.20 to 0.83) | 20/269 | 0.62 (0.34 to 1.13) |
| MSI-high CIMP-low/0 | 33 | 2/355 | 0.17 (0.02 to 1.22) | 4/355 | 0.22 (0.07 to 0.69) |
| MSI-high CIMP-high | 88 | 12/746 | 0.30 (0.14 to 0.64) | 39/746 | 0.77 (0.48 to 1.24) |
| MSS BRAF(+) | 52 | 25/365 | 1 (referent) | 28/365 | 1 (referent) |
| MSS BRAF(−) | 461 | 121/4162 | 0.74 (0.41 to 1.36) | 200/4162 | 1.12 (0.67 to 1.89) |
| MSI-high BRAF(+) | 53 | 11/410 | 1.09 (0.48 to 2.51) | 24/410 | 1.27 (0.68 to 2.36) |
| MSI-high BRAF(−) | 65 | 3/659 | 0.18 (0.05 to 0.61) | 18/659 | 0.65 (0.35 to 1.21) |
| CIMP-low/0 BRAF(+) | 31 | 17/199 | 1 (referent) | 20/199 | 1 (referent) |
| CIMP-low/0 BRAF(−) | 477 | 116/4410 | 0.46 (0.25 to 0.86) | 193/4410 | 0.56 (0.33 to 0.95) |
| CIMP-high BRAF(+) | 74 | 19/577 | 0.35 (0.16 to 0.79) | 32/577 | 0.49 (0.25 to 0.98) |
| CIMP-high BRAF(−) | 49 | 8/411 | 0.30 (0.11 to 0.82) | 25/411 | 0.63 (0.30 to 1.31) |
The multivariate analysis model includes age, year of diagnosis, sex, tumour location, stage, tumour grade, KRAS status, as well as BRAF status in the top analysis (for MSI/CIMP types), CIMP status in the middle analysis (for MSI/BRAF types) or MSI status in the bottom analysis (for CIMP/BRAF types).
CI, confidence interval; CIMP, CpG island methylator phenotype; HR, hazard ratio; MSI, microsatellite instability; MSS, microsatellite stable.