| All sizes | >5 mm | >9 mm | Advanced colonic neoplasia | ||
| No./total no. (% (95% CI)) | No./total no. (% (95% CI)) | No./total no. (% (95% CI)) | No./total no. (% (95% CI)) | ||
| OC | Sens | 110/113 (97.3 (92.4 to 99.4)) | 45/46 (97.8 (88.5 to 99.9)) | 25/25 (100.0 (86.3 to 100.0)) | 30/30 (100 (88.4 to 100)) |
| Spec | 116/194 (59.8 (52.5 to 66.8)) | 250/261 (95.8 (92.6 to 97.9)) | 278/282 (98.6 (96.4 to 99.6)) | 119/277 (43.0 (37.1 to 49)) | |
| PPV | 110/188 (58.5 (51.1 to 65.6)) | 45/56 (80.4 (67.6 to 89.8)) | 25/29 (86.2 (68.3 to 96.1)) | 30/188 (16.0 (11.0 to 22.0)) | |
| NPV | 116/119 (97.5 (92.8 to 99.5)) | 250/251 (99.6 (97.8 to 100)) | 278/278 (100.0 (98.7 to 100.0)) | 119/119 (100 (96.9 to 100)) | |
| FS | Sens | 81/113 (71.7 (62.4 to 79.8)) | 31/46 (67.4 (52.0 to 80.5)) | 17/25 (68.0 (46.5 to 85.1)) | 25/30 (83.3 (65.3 to 94.4)) |
| Spec | 138/194 (71.1 (64.2 to 77.4)) | 258/261 (98.9 (96.7 to 99.8)) | 281/282 (99.6 (98.0 to 100.0)) | 165/277 (59.6(53.5 to 65.4)) | |
| PPV | 81/137 (59.1 (50.4 to 67.4)) | 31/34 (91.2 (76.3 to 98.1)) | 17/18 (94.4 (72.7 to 99.9)) | 25/137 (18.2(12.2 to 25.7)) | |
| NPV | 138/170 (81.2 (74.5 to 86.8)) | 258/273 (94.5 (91.1 to 96.9)) | 281/289 (97.2 (94.6 to 98.8)) | 165/170 (97.1(93.3 to 99)) | |
| CTC | Sens | 95/113 (84.1 (76.0 to 90.3)) | 42/46 (91.3 (79.2 to 97.6)) | 23/25 (92.0 (74.0 to 99.0)) | 29/30 (96.7(82.8 to 99.9)) |
| Spec | 92/194 (47.4 (40.2 to 54.7)) | 243/261 (93.1 (89.3 to 95.9)) | 276/282 (97.9 (95.4 to 99.2)) | 109/277 (39.4 (33.6 to 45.4)) | |
| PPV | 95/197 (48.2 (41.1 to 55.4)) | 42/60 (70.0 (56.8 to 81.2)) | 23/29 (79.3 (60.3 to 92.0)) | 29/197 (14.7(10.1 to 20.5)) | |
| NPV | 92/110 (83.6 (75.4 to 90.0)) | 243/247 (98.4 (95.9 to 99.6)) | 276/278 (99.3 (97.4 to 99.0)) | 109/110 (99.1(95.0 to 100)) | |
| FOBT | Sens | 20/99 (20.2 (12.8 to 29.5)) | 7/40 (17.5 (7.3 to 32.8)) | 5/21 (23.8 (8.2 to 47.2)) | 5/25 (20.0 (6.8 to 40.7)) |
| Spec | 166/177 (93.8 (89.2 to 96.9)) | 212/236 (89.8 (85.2 to 93.4)) | 229/255 (89.8 (85.4 to 93.2)) | 225/251 (89.6 (85.2 to 93.1)) | |
| PPV | 20/31 (64.5 (45.4 to 80.8)) | 7/31 (22.6 (9.6 to 41.1)) | 5/31 (16.1 (5.5 to 33.7)) | 5/31 (16.1 (5.5 to 33.7)) | |
| NPV | 166/245 (67.8 (61.5 to 73.6)) | 212/245 (86.5 (81.6 to 90.5)) | 229/245 (93.5 (89.6 to 96.2)) | 225/245 (91.8 (87.7 to 94.9)) | |
| FIT | Sens | 25/102 (24.5 (16.5 to 34.0)) | 16/40 (40.0 (24.9 to 56.7)) | 7/21 (33.3 (14.6 to 57.0)) | 8/25 (32.0 (14.9 to 53.5)) |
| Spec | 163/183 (89.1 (83.6 to 93.2)) | 216/245 (88.2 (83.4 to 91.9)) | 226/264 (85.6 (80.8 to 89.6)) | 223/260 (85.8 (80.9 to 89.8)) | |
| PPV | 25/45 (55.6 (40.0 to 70.4)) | 16/45 (35.6 (21.9 to 51.2)) | 7/45 (15.6 (6.5 to 29.5)) | 8/45 (17.8 (8.0 to 32.1)) | |
| NPV | 163/240 (67.9 (61.6 to 73.8)) | 216/240 (90.0 (85.5 to 93.5)) | 226/240 (94.2 (90.4 to 96.8)) | 223/240 (92.9 (88.9 to 95.8)) | |
| FS + FOBT | Sens | 71/99 (71.7 (61.8 to 80.3)) | 28/40 (70.0 (53.5 to 83.4)) | 16/21 (76.2 (52.8 to 91.8)) | 20/25 (80.0 (59.3 to 93.2)) |
| Spec | 120/177 (67.8 (60.4 to 74.6)) | 211/236 (89.4 (84.8 to 93.0)) | 228/255 (89.4 (85.0 to 92.9)) | 143/251 (57.0 (50.6 to 63.2)) | |
| PPV | 71/128 (55.5 (46.4 to 64.3)) | 28/53 (52.8 (38.6 to 66.7)) | 16/43 (37.2 (23.0 to 53.3)) | 20/128 (15.6 (9.8 to 23.1)) | |
| NPV | 120/148 (81.1 (73.8 to 87.0)) | 211/223 (94.6 (90.8 to 97.2)) | 228/233 (97.9 (95.1 to 99.3)) | 143/148 (96.6 (92.3 to 98.9)) | |
| FS + FIT | Sens | 79/102 (77.5 (68.1 to 85.1)) | 32/40 (80.0 (64.4 to 90.9)) | 15/21 (71.4 (47.8 to 88.7)) | 21/25 (84.0(63.9 to 95.5)) |
| Spec | 119/183 (65.0 (57.6 to 71.9)) | 215/245 (87.8 (83.0 to 91.6)) | 225/264 (85.2 (80.4 to 89.3)) | 138/260 (53.1 (46.8 to 59.3)) | |
| PPV | 79/143 (55.2 (46.7 to 63.6)) | 32/62 (51.6 (38.6 to 64.5)) | 15/54 (27.8(16.5 to 41.6)) | 21/143 (14.7 (9.3 to 21.6)) | |
| NPV | 119/142 (83.8 (76.7 to 89.4)) | 215/223 (96.4 (93.1 to 98.4)) | 225/231 (97.4(94.4 to 99.0)) | 138/142 (97.2 (92.9 to 99.2)) |
Analysis according to the patient.
CTC, CT colonography; FIT, faecal immunochemical stool testing; FOBT, faecal occult blood testing; FS, flexible sigmoidoscopy; NPV, negative predictive value; OC optical colonoscopy; PPV, positive predictive value; Sens, sensitivity; Spec, specificity.