| Characteristic | All patients (n = 200) | Patients with PRSS1 mutations (n = 135) | Patients without detected PRSS1 mutation (n = 65†) | p Value |
| Chronic use of analgesics (%)* (md = 2) | 20 (10) | 14 | 6 | NS |
| Endoscopic treatment (%) (md = 3) | 31 (16) | 24 | 7 | NS |
| Surgical treatment (%) (md = 1) | 49 (24) | 39 | 10 | NS |
*At least one period of chronic use >3 months.
†Including nine patients deceased before 1996, in whom PRSS1 mutation could not be searched for.
md, Missing data; NS, not significant; PRSS1, cationic trypsinogen gene.