Table 3

Liver biopsy features (n = 29)

Histological findingNumber (%)
Steatosis score
    0, Minimal (<5%)0
    1, Mild (>5–33%)5 (17.2)
    2, Moderate (>33% and 66%)11 (37.9)
    3, Severe (>66%)13 (44.8)
Lobular inflammation score
    0, No foci1 (3.4)
    1, Mild26 (89.7)
    2, Moderate1 (3.4)
    3, Severe1 (3.4)
Hepatocellular ballooning
    0, None24 (82.8)
    1, Few5 (17.2)
    2, Prominent0
NAFLD activity score
    1–25 (17.2)
    3–420 (70)
    5 or more4 (13.8)
Fibrosis
    Stage 012 (41.3)
    Stage 1 Perisinusoidal or periportal
        1A Delicate perisinusoidal3 (10.3)
        1B Dense perisinusoidal1 (3.5)
        1C Periportal only2 (6.9)
    Stage 2 Perisinusoidal and periportal5 (17.2)
    Stage 3 Bridging fibrosis4 (13.8)
    Stage 4 Cirrhosis2 (6.9)
Mallory’s hyaline4 (13.8)
  • Liver biopsy features were graded and staged according to the scoring system proposed by Kleiner et al.31 The grade of steatosis (0–3), lobular inflammation (0–3), and ballooning (0–2) were then combined to determine the non-alcoholic fatty liver disease (NAFLD) activity score (0–8) as proposed.31