Odds ratios for Barrett’s oesophagus based on change in weight between 1976 and the index endoscopy
| Lost >5 lbs (>2.3 kg) | Stable weight | Gained 5–24.9 lbs (2.3–11.3 kg) | Gained 25–49.9 lbs (11.4–22.6 kg) | Gained ⩾50 lbs (⩾22.7 kg) | |
| Entire upper gastrointestinal endoscopy cohort | |||||
| Cases/women,(n/n) | 19/1375 | 46/2942 | 92/6038 | 67/3773 | 26/1224 |
| Multivariate OR (95% CI) | 0.80 (0.46 to 1.39) | 1.0 | 0.91 (0.63 to 1.31) | 0.95 (0.64 to 1.41) | 1.08 (0.64 to 1.83) |
| Participants of the upper gastrointestinal endoscopy cohort with BMI <25 kg/m2 in 1976 | |||||
| Cases/women,(n/n) | 6/624 | 35/2132 | 71/4617 | 41/2612 | 18/624 |
| Multivariate OR (95% CI) | 0.53 (0.22 to 1.29) | 1.0 | 0.86 (0.57 to 1.32) | 0.75 (0.46 to 1.22) | 1.21 (0.65 to 2.26) |
Multivariate ORs are adjusted for year of endoscopy; age (5-year categories); physical activity (<1.7, 1.7–4.5, 4.6–10.5, 10.6–22.1 and >22.1 metabolic equivalent task score per week); smoking history (never, former, current); daily caloric intake/day (quartiles); alcohol consumption (0, 0.1–4.9, 5.0–15.0 and >15 g/day); postmenopausal hormone use (premenopausal, never, past, current); and history of diabetes. Analysis of the entire upper gastrointestinal endoscopy cohort also controlled for body mass index at baseline.