OS (nā=ā25) | SEM | RS (nā=ā37) | SEM | p Value | |
Crypt length (nm) | 461 | 19.5 | 493 | 15.7 | 0.21 |
Crypt width (nm) | 89 | 2.5 | 89 | 2.0 | 0.96 |
Crypt mitotic cell count | 6.6 | 0.74 | 6.7 | 0.56 | 0.93 |
Mitotic cells in top half of crypt (%) | 8.2 | 1.6 | 4.6 | 1.1 | 0.07 |
MIB1 proliferation index | 0.42 | 0.02 | 0.45 | 0.02 | 0.42 |
Values in the table are least square means adjusted for age, sex, site of biopsy and respective pretreatment measurements. Crypt mitotic cell count is the average number of mitotic cells per whole crypt calculated after counting a minimum of 10 microdissected whole crypts from apparently normal flat mucosa. MIB1 proliferation index is the ratio of the number of MIB1-positive cells to total cells in tumour tissue.
MIB1, mindbomb homologue 1; OS, ordinary starch; RS, resistant starch.