Table 1 Plasma triglyceride levels and histological scores for pancreatic injury
Wild-type control (n = 6)LPL-deficient control (n = 8)Wild-type after caerulein (n = 8)LPL-deficient after caerulein (n = 6)
Plasma triglycerides (mg/dl)80.64 (8.45)2162.2 (864.7)**82.47 (8.63)1761.3 (613.3)**
Oedema1 (0)1 (0)3.13 (0.83)3.67 (0.82)
Haemorrhage1 (0)1 (0)1.63 (0.74)4.00 (1.10)**
Necrosis1 (0)1 (0)2.75 (0.46)4.17 (0.41)*
Inflammatory infiltration1 (0)1 (0)3.50 (0.93)4.33 (0.82)
Total4 (0)4 (0)11.00 (1.85)16.17 (2.14)
  • Pancreatitis was induced by seven intraperitoneal injections of caerulein 20 μg/kg body weight in 0.9% sodium chloride. Animals injected only with the saline vehicle served as controls. Mouse pancreas was sectioned at 2 μm and stained with Carazzi haematoxylin & eosin. Two investigators blinded to experimental treatment scored the degree of pancreatic injury by light microscopy, evaluating the severity of oedema, inflammation, haemorrhage and necrosis. The results were analysed using the Mann–Whitney rank sum test. For further details see the supplementary information.

  • Results are expressed as mean (SEM).

  • *p<0.01; **p<0.001.