Table 1 Differential diagnosis for eosinophilic oesophagitis
DisorderFeature
PrimaryPrimary eosinophilic oesophagitis
  • atopic

  • non-atopic

  • familial

Secondary: eosinophilicHypereosinophilic syndrome
relatedEosinophilic gastroenteritis
Secondary: non-eosinophilicGastro-oesophageal reflux disease
relatedRecurrent vomiting
Infection (parasites such as helminths and fungi)
Crohn’s disease
Oesophageal gastrointestimal stromal tumour
Myeloproliferative disorders
Carcinomatosis
Allergic vasculitis
Connective tissue diseases (scleroderma)
Drugs/iatrogenic
  • Primary (idiopathic) disorders are those in which no other inciting cause is known. Secondary disorders are inflammatory, infectious or hypersensitivity illnesses which result in oesophageal eosinophilia.