Table 4 Histopathology of eosinophilic oesophagitis
GORDEosinophilic oesophagitis
Eosinophilic infiltration (squamous epithelium)<10/hpf>15/hpf (peak count)
Other features
  • Oesophagitis (usually distal)

  • Oesophagitis (proximal and/or distal, may be patchy or segmental)

  • Intestinal metaplasia

  • Basal zone hyperplasia

  • Increased papilla

  • Superficial eosinophilic layering or aggregates

  • Eosinophilic microabscesses

  • A minimum of >15 eosinophils in at least one high-power field (×400) is suggested for the diagnosis of eosinophilic oesophagitis.41 No definite cut-off criterion distinguishes eosinophilic oesophagitis from gastro-oesophageal reflux based solely on number of eosinophils.

  • This table is modified from Yan and Shaffer,21 with permission from the publishers.

  • GORD, gastro-oesophageal reflux disease; hpf, high-power field.