Table 6 Differential diagnosis for eosinophilic gastroenteritis and colitis
DisorderFeature
PrimaryPrimary eosinophilic gastroenteritis
  • mucosal

  • muscularis

  • (sub)serosal

Primary eosinophilic colitis
  • atopic

  • non-atopic

Secondary: eosinophilicHypereosinophilic syndrome
relatedProtein hypersensitivity enteropathy
Secondar: non-Inflammatory bowel disease
eosinophilic relatedCoeliac disease
Infection (Helicobacter pylori, tuberculosis, parasites such as helminths and fungi, Clostridium difficile, Shigella, Escherichia coli)
Lymphangiectasia
Lymphoma/carcinoma
Connective tissue disease (scleroderma)
Vasculitis (polyarteritis nodosa, Churg–Strauss)
Graft versus host disease
Systemic mastocytosis
Drugs/iatrogenic