Table 2 Haplotype analysis using single nucleotide polymorphisms (SNPs) covering collagen type III alpha I (COL3A1)
SNPsHaplotypeGastro-oesophageal reflux disease
Trios, allTrios, malesCase–control, all
p Valuep ValuepcorrOR (95% CI)p ValueOR (95% CI)
4:52:10.000960.000180.00263.00 (1.63 to 5.50)0.00260.61 (0.43 to 0.85)
4:52:20.000190.0000020.000090.40 (0.26 to 0.59)NS
5–62:2NSNSNSNo data0.00411.42 (1.11 to 1.81)
  • Highly associated haplotypes were found in both the Trio cohort and in the adult case–control cohort. The association in Trios was found in males only.

  • CI, confidence interval; NS, not significant OR, odds ratio; pcorr, p value adjusted for multiple testing.