Table 4 Synthesis of diagnostic indices
Indexα-Fetoprotein aloneProteasome aloneProteasome and α-fetoprotein
No%No%No%
Matched5768.76881.96375.9
    no HCC ( =  specificity)1854.53297.01751.5
    HCC ( =  sensitivity)3978.03672.04692.0
Positive predictive value72.297.374.25
Difference with positive prevalence12.037.114.0
Negative predictive value62.169.6581.0
Difference with negative prevalence22.3629.841.2
χ2 test7.8935.5317.68
    p Value0.005<0.001<0.001
Youden’s index, J0.3250.6900.435
  • The χ2 test was used to compare the distribution of patients with hepatocellular carcinoma (HCC) above and under the cut-off value for α-fetoprotein (4.65 ng/ml), for proteasome (2900 ng/ml) and for both. For Youden’s index see ‘Patients and methods’ section.

  • HCC, hepatocellular carcinoma.